(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxylic acid;2,4-dimethylazetidine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 英文名称: (6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxylic acid;2,4-dimethylazetidine
• 化学式: C21H27N3O2
• 分子量: 353.5
• InChiKey: QKPRVWDQSZDUEI-BWTUWSSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  68.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Biomarkers in inflammatory bowel disease
  申请人：University of Tromsø

  公开号：US10012654B2

  公开（公告）日：2018-07-03

  The present invention provides a method of determining whether a patient with inflammatory bowel disease (IBD) and who has been treated with anti TNFα therapy is in immunological remission (IR), said method comprising determining the level of a cytokine selected from TNFα, IL-17 and IFN-y in a Gl mucosal sample from said patient. Also provided are methods of prognosis and treatment using said method of determination, in particular discontinuing treatment if said patient is in IR and continuing treatment if said patient is not in IR.

  本发明提供了一种确定已接受抗 TNFα 治疗的炎症性肠病（IBD）患者是否处于免疫学缓解期（IR）的方法，所述方法包括确定所述患者 Gl 粘膜样本中选自 TNFα、IL-17 和 IFN-y 的细胞因子水平。还提供了使用所述测定方法进行预后和治疗的方法，特别是如果所述患者处于IR期，则停止治疗，如果所述患者未处于IR期，则继续治疗。
• Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
  申请人：Cyrano Therapeutics, Inc.

  公开号：US10598672B2

  公开（公告）日：2020-03-24

  Disclosed herein are methods for diagnosing a subject with loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia.

  本文公开了用于诊断味觉或嗅觉丧失和/或失真（如嗅觉减退、嗅觉障碍、无嗅觉、幻嗅觉、低嗅觉、失嗅觉、幻嗅觉和/或老嗅觉）的方法。本文还公开了用于治疗受试者味觉或嗅觉丧失和/或扭曲的方法和组合物，例如，味觉减退症、味觉失调症、无嗅症、幻觉症、味觉减退症、味觉失调症、幻觉症和/或老年性味觉失调症。
• Methods of treating food allergy conditions
  申请人：Palo Alto Investors LP

  公开号：US11045454B2

  公开（公告）日：2021-06-29

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.

  本文提供了治疗食物过敏症的方法。这些方法的各个方面包括以有效治疗食物过敏症的方式向有需要的受试者施用迷幻剂。有效施用迷幻剂可包括以有效治疗受试者食物过敏症的量施用迷幻剂。在某些情况下，受试者已知患有食物过敏症。
• BIOMARKERS IN INFLAMMATORY BOWEL DISEASE
  申请人：University of Tromsø

  公开号：EP2936162A1

  公开（公告）日：2015-10-28
• METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL
  申请人：Henkin, Robert I.

  公开号：EP3108245A1

  公开（公告）日：2016-12-28