7-[(1S)-1-(chloromethyl)-5-(methylamino)-1,2-dihydrobenzo[e]indole-3-carbonyl]-1,2,3,6-tetrahydro-as-indacene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-[(1S)-1-(chloromethyl)-5-(methylamino)-1,2-dihydrobenzo[e]indole-3-carbonyl]-1,2,3,6-tetrahydro-as-indacene-3-carboxamide
• 化学式: C₂₈H₂₆ClN₃O₂
• 分子量: 472.0
• InChiKey: VQVPIEOYRCKYMA-PLEWWHCXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
  申请人：BioAlliance C.V.

  公开号：US20140193437A1

  公开（公告）日：2014-07-10

  The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.