Methyl 5-(hydroxysulfamoyl)furan-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: Methyl 5-(hydroxysulfamoyl)furan-2-carboxylate
• 英文别名: methyl 5-(hydroxysulfamoyl)furan-2-carboxylate
• 化学式: C₆H₇NO₆S
• 分子量: 221.19
• InChiKey: MSNCYLJRUWYHCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS
  申请人：CARDIOXYL PHARMACEUTICALS

  公开号：US20150366977A1

  公开（公告）日：2015-12-24

  The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

  本公开提供了含有N-取代羟胺衍生物的亚硝酰基供体药物组合物。该组合物在治疗心血管疾病（如心力衰竭）方面具有高效性，具有适当的毒理学特性，并且对于静脉或口服给药具有足够的稳定性。
• Pharmaceutical compositions comprising nitroxyl donors
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US10245249B2

  公开（公告）日：2019-04-02

  The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

  本公开提供了由 N-取代的羟胺衍生物组成的硝基捐献药物组合物。这些组合物在治疗心血管疾病（如心力衰竭）方面疗效显著，具有合适的毒理学特征，并且足够稳定，可用于静脉注射或口服给药。
• Method of administering nitroxyl donating compounds
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US11083704B2

  公开（公告）日：2021-08-10

  The disclosed subject matter provides methods of using nitroxyl donating compounds and pharmaceutical compositions comprising such compounds in a dose escalation regimen.

  所公开的主题提供了在剂量递增方案中使用硝基供体化合物和包含此类化合物的药物组合物的方法。
• EP3427728A1
  申请人：——

  公开号：EP3427728A1

  公开（公告）日：2019-01-16
• METHOD OF ADMINISTERING NITROXYL DONATING COMPOUNDS
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US20190343790A1

  公开（公告）日：2019-11-14

  The disclosed subject matter provides methods of using nitroxyl donating compounds and pharmaceutical compositions comprising such compounds in a dose escalation regimen.