(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;1,3-bis(2-chloroethyl)-1-nitrosourea;(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;1,3-bis(2-chloroethyl)-1-nitrosourea;(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
• 化学式: C52H66Cl2N4O15
• 分子量: 1058.0
• InChiKey: DTMKYYBGCIGSJH-WDEACNFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.76
• 重原子数：
  73
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  305
• 氢给体数：
  8
• 氢受体数：
  17

文献信息

• [EN] BIOCOMPATIBLE POLYMER COMPOSITIONS FOR TISSUE VOID FILLING<br/>[FR] COMPOSITIONS POLYMÈRES BIOCOMPATIBLES POUR REMPLISSAGE DE VIDE TISSULAIRE
  申请人：UNIV RUTGERS

  公开号：WO2014116716A1

  公开（公告）日：2014-07-31

  Biodegradable, bioabsorhahie cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.