(4S)-4-methyl-3-[2-[[(1S)-1-(6-methylnaphthalen-2-yl)ethyl]amino]pyrimidin-4-yl]-4-phenyl-1,3-oxazolidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4S)-4-methyl-3-[2-[[(1S)-1-(6-methylnaphthalen-2-yl)ethyl]amino]pyrimidin-4-yl]-4-phenyl-1,3-oxazolidin-2-one
• 化学式: C₂₇H₂₆N₄O₂
• 分子量: 438.5
• InChiKey: OXPSPJFIPWYBSO-UZTOHYMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
  申请人：VESTAS WIND SYSTEMS A/S

  公开号：US20140235620A1

  公开（公告）日：2014-08-21

  The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

  该发明涉及公式（I）的化合物或其药用盐，其中R1-R6在此处定义。该发明还涉及含有公式（I）化合物的组合物，以及利用这些化合物抑制具有新型活性的突变IDH蛋白。该发明还涉及利用公式（I）的化合物治疗与这些突变IDH蛋白相关的疾病或紊乱，包括但不限于细胞增殖紊乱，如癌症。
• US8957068B2
  申请人：——

  公开号：US8957068B2

  公开（公告）日：2015-02-17