(2S,3S)-5-methyl-2,3-diphenyl-6-(2,4,6-trimethylphenyl)-3,5-dihydro-2H-imidazo[1,2-c]quinazoline

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (2S,3S)-5-methyl-2,3-diphenyl-6-(2,4,6-trimethylphenyl)-3,5-dihydro-2H-imidazo[1,2-c]quinazoline
• 化学式: C₃₂H₃₁N₃
• 分子量: 457.6
• InChiKey: HBHJQMNOKCUXJO-GVJSTEMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  18.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• LIGAND FORMING ASYMMETRICAL TRANSFORMATION CATALYST FOR MAKING NEW PHARMACEUTICALS
  申请人：FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION

  公开号：US20140336402A1

  公开（公告）日：2014-11-13

  The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided.
• US8822483B2
  申请人：——

  公开号：US8822483B2

  公开（公告）日：2014-09-02
• US8975269B2
  申请人：——

  公开号：US8975269B2

  公开（公告）日：2015-03-10