Methoxymethane;6,6,9-trimethyl-3-pentylbenzo[c]chromen-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Methoxymethane;6,6,9-trimethyl-3-pentylbenzo[c]chromen-1-ol
• 英文别名: methoxymethane;6,6,9-trimethyl-3-pentylbenzo[c]chromen-1-ol
• 化学式: C23H32O3
• 分子量: 356.5
• InChiKey: ADIABYPTPREBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.99
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CANNABINOID CONTAINING TARGETING LIPOSOMES<br/>[FR] LIPOSOMES DE CIBLAGE CONTENANT DES CANNABINOÏDES
  申请人：NEXTAGE CANNABIS INNOVATION LTD

  公开号：WO2021038574A1

  公开（公告）日：2021-03-04

  Described herein are liposomes containing modified targeting peptides. Liposomes preferably comprise a lipid-based bilayer and at least one cannabinoid. Also provided herein are methods for making the liposomes, and methods for treatment of diseases of the CNS using the liposomes.

  本文描述了含有改良靶向肽的脂质体。脂质体最好包括基于脂质的双层结构和至少一种大麻素。本文还提供了制备脂质体的方法，以及利用脂质体治疗中枢神经系统疾病的方法。
• [EN] COMPOSITIONS CONTAINING CANNABINOID ANALOG CONJUGATES AND METHODS OF USE<br/>[FR] COMPOSITIONS CONTENANT DES CONJUGUÉS D'ANALOGUES CANNABINOÏDES ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：VYRIPHARM ENTPR LLC

  公开号：WO2019018536A1

  公开（公告）日：2019-01-24

  Provided here are compositions containing a conjugate of a label, a chelator, and a cannabinoid analog and methods for diagnosing, treating, or monitoring the progression of a cancer or a neurologic disorder using these compositions. Also provided here are methods of synthesizing these compositions and kits for delivery of these compositions as imaging and therapeutic agents.

  在这里提供了包含标签的共轭物、螯合剂和大麻素类似物的组合物，以及使用这些组合物诊断、治疗或监测癌症或神经系统疾病进展的方法。还提供了合成这些组合物的方法以及用于传递这些组合物作为成像和治疗剂的工具包。
• [EN] METHODS FOR PREPARING CANNABINOIDS BY BASE-PROMOTED DOUBLE-BOND MIGRATION<br/>[FR] PROCÉDÉS DE PRÉPARATION DE CANNABINOÏDES PAR MIGRATION À DOUBLE LIAISON ACTIVÉE PAR LA BASE
  申请人：CANOPY GROWTH CORP

  公开号：WO2020248059A1

  公开（公告）日：2020-12-17

  Disclosed is a method for converting a first cannabinoid into a second cannabinoid that is a regioisomer of the first cannabinoid. The method comprising contacting the first cannabinoid with: (i) a base having a pKb that is less than a critical pKb for the first cannabinoid; and (ii) a solvent system comprising a polar solvent such as dimethyl sulfoxide (DMSO), triethylamine (TEA), or a combination thereof.

  揭示了一种将第一类大麻素转化为第二类大麻素的方法，该第二类大麻素是第一类大麻素的异构体。该方法包括将第一类大麻素与以下物质接触：(i) 具有比第一类大麻素的临界pKb更小的pKb的碱；以及 (ii) 包括极性溶剂的溶剂系统，如二甲基亚砜（DMSO）、三乙胺（TEA）或二者的组合。
• [EN] IMPROVED METHODS FOR CANNABINOID ISOMERIZATION<br/>[FR] PROCÉDÉS AMÉLIORÉS D'ISOMÉRISATION DE CANNABINOÏDES
  申请人：CANOPY GROWTH CORP

  公开号：WO2020248062A1

  公开（公告）日：2020-12-17

  Disclosed herein is a method for converting a first cannabinoid into a composition comprising a second cannabinoid and a third cannabinoid, in which the second cannabinoid and the third cannabinoid are each isomers of the first cannabinoid. The composition has a second cannabinoid:third cannabinoid ratio of greater than 1.0:1.0. The method comprises contacting the first cannabinoid with a Lewis-acidic heterogeneous reagent under reaction conditions comprising: (i) a protic-solvent environment, an aprotic-solvent environment, or a solvent-free environment; (ii) a reaction temperature that is within a target reaction-temperature range for the Lewis- acidic heterogeneous reagent and the solvent/solvent free environment; and (iii) a reaction time that is within a target reaction-time range for the Lewis-acidic heterogeneous reagent, the solvent/solvent-free environment, and the reaction temperature.

  本公开涉及一种将第一大麻素转化为包含第二大麻素和第三大麻素的组合物的方法，其中第二大麻素和第三大麻素分别是第一大麻素的异构体。该组合物具有大于1.0:1.0的第二大麻素:第三大麻素比率。该方法包括将第一大麻素与Lewis酸性杂质试剂在反应条件下接触，包括：（i）具有脂溶剂环境、无水脂溶剂环境或无溶剂环境；（ii）反应温度在Lewis酸性杂质试剂和溶剂/无溶剂环境的目标反应温度范围内；（iii）反应时间在Lewis酸性杂质试剂、溶剂/无溶剂环境和反应温度的目标反应时间范围内。
• [EN] METHODS FOR CONVERTING TETRAHYDROCANNABINOLIC ACID INTO CANNABINOLIC ACID<br/>[FR] PROCÉDÉS DE CONVERSION DE L'ACIDE TÉTRAHYDROCANNABINOLIQUE EN ACIDE CANNABINOLIQUE
  申请人：CANOPY GROWTH CORP

  公开号：WO2021035342A1

  公开（公告）日：2021-03-04

  Disclosed herein is a method for converting tetrahydrocannabinolic acid (THCA) to cannabinolic acid (CBNA). The method comprises contacting an input material comprising THCA with a benzoquinone reagent under reaction conditions comprising: (i) a reaction temperature that is within a target reaction-temperature range; and (ii) a reaction time that is within a target reaction-time range, to provide an output material in which at least a portion of the THCA from the input material has been converted into CBNA.

  本文揭示了一种将四氢大麻酸（THCA）转化为大麻酸（CBNA）的方法。该方法包括将含有THCA的输入物料与苯醌试剂在反应条件下接触，所述反应条件包括：（i）反应温度在目标反应温度范围内；以及（ii）反应时间在目标反应时间范围内，从而提供输出物料，其中输入物料中的至少一部分THCA已被转化为CBNA。