2-[(4Z)-4-[4-(3,4-dimethoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-3-oxocyclohexa-1,5-dien-1-yl]oxyacetohydrazide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-[(4Z)-4-[4-(3,4-dimethoxyphenyl)-1,2-dihydropyrazol-3-ylidene]-3-oxocyclohexa-1,5-dien-1-yl]oxyacetohydrazide
• 化学式: C₁₉H₂₀N₄O₅
• 分子量: 384.4
• InChiKey: LSZDQVJQBHJLSE-UYRXBGFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR
  申请人：RYDER Sean

  公开号：US20110077250A1

  公开（公告）日：2011-03-31

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
• [EN] COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR<br/>[FR] COMPOSÉS DE MODULATION DES PROTÉINES DE LIAISON À L'ARN ET APPLICATIONS ASSOCIÉES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2010151799A2

  公开（公告）日：2010-12-29

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.