1-[6-(2,3-Dihydroindol-1-ium-1-ylidene)-9-[2-(4-methylpiperidin-1-yl)sulfonylphenyl]xanthen-3-yl]-2,3-dihydroindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-[6-(2,3-Dihydroindol-1-ium-1-ylidene)-9-[2-(4-methylpiperidin-1-yl)sulfonylphenyl]xanthen-3-yl]-2,3-dihydroindole
• 英文别名: 1-[6-(2,3-dihydroindol-1-ium-1-ylidene)-9-[2-(4-methylpiperidin-1-yl)sulfonylphenyl]xanthen-3-yl]-2,3-dihydroindole
• 化学式: C41H38N3O3S+
• 分子量: 652.8
• InChiKey: MUQYIQPTVLPREV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  48
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
  申请人：Ventana Medical Systems, Inc.

  公开号：US20170089911A1

  公开（公告）日：2017-03-30

  Disclosed herein are novel quinone methide analog precursors and embodiments of a method and a kit of using the same for detecting one or more targets in a biological sample. The method of detection comprises contacting the sample with a detection probe, then contacting the sample with a labeling conjugate that comprises an enzyme. The enzyme interacts with a quinone methide analog precursor comprising a detectable label, forming a reactive quinone methide analog, which binds to the biological sample proximally to or directly on the target. The detectable label is then detected. In some embodiments, multiple targets can be detected by multiple quinone methide analog precursors interacting with different enzymes without the need for an enzyme deactivation step.
• PROXIMITY ASSAYS USING CHEMICAL LIGATION AND HAPTEN TRANSFER
  申请人：Ventana Medical Systems, Inc.

  公开号：US20170254813A1

  公开（公告）日：2017-09-07

  Methods for in situ detecting proximity of two targets of interest featuring an antibody conjugated with a cleavable bridge component having a detectable moiety and an antibody conjugated with a non-cleavable bridge component. The bridge components each have a chemical ligation group adapted to form a covalent bond under particular conditions and when the targets are in close proximity. Following covalent bond formation, the cleavable bridge component can be cleaved from the antibody, effectively transferring the detectable moiety to the non-cleavable bridge component. Detection of the detectable moiety is indicative of the targets being in close proximity. The methods are compatible with both chromogenic and fluorogenic detection systems. The methods may be used to perform assays wherein one or more than one proximity event is detected on the same slide.
• [EN] DIGITALLY ENHANCED MICROSCOPY FOR MULTIPLEXED HISTOLOGY<br/>[FR] MICROSCOPIE AMÉLIORÉE NUMÉRIQUEMENT POUR HISTOLOGIE MULTIPLEXÉE
  申请人：VENTANA MED SYST INC

  公开号：WO2014143155A1

  公开（公告）日：2014-09-18

  A multispectral imaging system (100) for imaging a specimen located on a microscope slide (134) comprise: an imaging apparatus (112) including an illuminator (140) with a plurality of different color light sources (180a-d) for sequentially producing light for sequentially illuminating the specimen, an image capture device (120) for capturing a plurality of specimen images each corresponding to the specimen being exposed to light from a respective one of the light sources, and a processing device (122) configured to produce contrast enhanced color image data and/or spectrally deconvolved image data based on the captured specimen images; at least one lens positioned along an optical path extending from the specimen to the image capture device; and a display (114) in communication with the imaging apparatus and configured to display contrast enhanced output (144) and/or spectrally deconvolved output (144) of the specimen based on the contrast enhanced color image data and/or spectrally deconvolved image data from the processing device.