N-[4-hydroxy-3-(8-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[4-hydroxy-3-(8-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide
• 化学式: C₂₇H₂₁NO₅S
• 分子量: 471.5
• InChiKey: PPSYWEPYYTUADK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Methods and compositions for treatment of fibrosis
  申请人：Baylor College of Medicine

  公开号：US10112933B2

  公开（公告）日：2018-10-30

  Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction of the risk of fibrosis. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体纤维化风险的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低纤维化的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。
• Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
  申请人：Baylor College of Medicine

  公开号：US10676455B2

  公开（公告）日：2020-06-09

  Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体发生选自肌肉萎缩、肌无力、恶病质及其组合的疾病的风险或严重程度的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低肌肉萎缩的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。
• EP3021839B1
  申请人：——

  公开号：EP3021839B1

  公开（公告）日：2021-06-23
• COMPOSITIONS FOR PREVENTION OF ALLERGIC REACTION
  申请人：Baylor College of Medicine

  公开号：EP3021840B1

  公开（公告）日：2020-03-11
• METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS
  申请人：Baylor College Of Medicine

  公开号：EP3021839A1

  公开（公告）日：2016-05-25