N-碘乙酰基-N′-(8-磺基-1-萘基)乙二胺 | 36930-64-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-碘乙酰基-N′-(8-磺基-1-萘基)乙二胺
• 中文别名: 8-[2-(2-碘乙酰氨基)乙基氨基]-1-萘磺酸；8-[2-(2-碘乙酰氨基)乙氨基]-1-萘磺酸
• 英文名称: 1,8-I-Aedans
• 英文别名: 8-[2-[(2-iodoacetyl)amino]ethylamino]naphthalene-1-sulfonic acid
• CAS: 36930-64-0
• 化学式: C₁₄H₁₅IN₂O₄S
• mdl: MFCD27978024
• 分子量: 434.25
• InChiKey: ZDIHEEHLFMMPKM-UHFFFAOYSA-N

物化性质

• 熔点：
  198-200°C
• 溶解度：
  在pH7的磷酸盐缓冲液中溶解度至少0.05MDMF、DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• New biologically active fluorescent cyclic nucleotides
  申请人：UNIVERSITA' DEGLI STUDI DI PARMA

  公开号：EP0205005A2

  公开（公告）日：1986-12-17

  Sybthesis of new biologically active fluorescentcyclic nucleotides of general formula: wherein X=OH and Y=NH2 or X=NH2 and Y=H and L is a fluorescent group of the class of 5 (or 6)-thioacetamido-fluorescein or of 5(or 8)-(2 thioacetamido-ethyl)-amino- naphtalene -1-sulphonic acid.

  通式如下的新的具有生物活性的荧光环核苷酸的合成： 其中 X=OH 和 Y=NH2 或 X=NH2 和 Y=H 以及 L 是 5（或 6）-硫代乙酰胺基-荧光素或 5（或 8）-(2-硫代乙酰胺基-乙基)-氨基-萘-1-磺酸类荧光基团。
• Labelling of peptides and proteins
  申请人：Nordheim, Alfred, Prof. Dr.

  公开号：EP1059531A1

  公开（公告）日：2000-12-13

  This invention relates to methods for labelling peptides and/or proteins in preparative and analytical electrophoresis, especially as sample preparation for isoelectric focussing, wherein side chains of specific amino acid residues of the peptides and/or proteins are derivatized and labelled. The purpose of the invention is to control the isoelectric point of the peptides and/or proteins to permit isoelectric focussing of the samples with reliable results. In one embodiment of the invention cysteine residues of the peptides and/or proteins are alkylated, such that the modified amino acid side chain can be labelled, e.g. iodinated, along with tyrosine during standard conditions for tyrosine labelling. The invention permits unincorporated label to be electrophoretically removed from the sample during subsequent electrophoresis, thus dramatically improving the ratio of specific protein-bound signal to non-specific background signal upon isotopic detection.

  本发明涉及在制备和分析电泳中对肽和/或蛋白质进行标记的方法，特别是作为等电点聚焦的样品制备，其中对肽和/或蛋白质的特定氨基酸残基的侧链进行衍生化和标记。本发明的目的是控制肽和/或蛋白质的等电点，以便对样品进行等电聚焦，并获得可靠的结果。在本发明的一个实施方案中，肽和/或蛋白质的半胱氨酸残基被烷基化，这样，在酪氨酸标记的标准条件下，经修饰的氨基酸侧链可与酪氨酸一起被标记，如碘化。本发明允许在随后的电泳过程中将未结合的标签从样品中电泳去除，从而大大提高了同位素检测时特异性蛋白质结合信号与非特异性背景信号的比率。
• Peptides antibodies directed thereagainst for diagnosing and treating amyloid-associated diseases
  申请人：Tel Aviv University Future Technology Development L.P.

  公开号：EP2719394A1

  公开（公告）日：2014-04-16

  The present invention relates to an isolated peptide as set forth in SEQ ID NO: 145.

  本发明涉及 SEQ ID NO: 145 所述的分离肽。
• Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases
  申请人：Gazit Ehud

  公开号：US20050020809A1

  公开（公告）日：2005-01-27

  Peptides having at least 2 amino acid residues and no more than 15 amino acid residues are provided. The peptides comprise amino acid sequence X-Y or Y-X, wherein X is an aromatic amino acid and Y is any amino acid other than glycine. Also provided are pharmaceutical compositions and kits including such peptides as well as methods using same for diagnosing and treating amyloid associated diseases.

  提供了至少具有 2 个氨基酸残基但不超过 15 个氨基酸残基的多肽。 这些多肽包括氨基酸序列 X-Y 或 Y-X，其中 X 是芳香族氨基酸，Y 是除甘氨酸以外的任何氨基酸。 此外，还提供了包括这种多肽的药物组合物和试剂盒，以及用其诊断和治疗淀粉样蛋白相关疾病的方法。
• PEPTIDES ANTIBODIES DIRECTED THEREAGAINST AND METHODS USING SAME FOR DIAGNOSING AND TREATING AMYLOID-ASSOCIATED DISEASES
  申请人：Tel Aviv University Future Technology Development L.P.

  公开号：EP1534310A2

  公开（公告）日：2005-06-01

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