3,3-dimethyl-N-[(4-methylsulfonylphenyl)methyl]-5-(4-propan-2-ylpyrimidin-5-yl)-2H-pyrrolo[3,2-b]pyridine-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 3,3-dimethyl-N-[(4-methylsulfonylphenyl)methyl]-5-(4-propan-2-ylpyrimidin-5-yl)-2H-pyrrolo[3,2-b]pyridine-1-carboxamide
• 化学式: C₂₅H₂₉N₅O₃S
• 分子量: 479.603
• InChiKey: KULJVRUSEGXUJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] AZAINDOLE COMPOUNDS AS MODULATORS OF RORC<br/>[FR] COMPOSÉS D'AZAINDOLE À TITRE DE MODULATEURS DE RORC
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2015017335A1

  公开（公告）日：2015-02-05

  The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

  本发明涵盖了式（I）的化合物，其中变量在此处定义，适用于调节RORC并治疗与RORC调节相关的疾病。本发明还涵盖了制备式（I）化合物的方法以及含有它们的药物制剂。
• COMPOUNDS AS MODULATORS OF RORC
  申请人：COOK Brian Nicholas

  公开号：US20160159791A1

  公开（公告）日：2016-06-09

  The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of RORC and the treatment of diseases related to the modulation of RORC. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
• US9745297B2
  申请人：——

  公开号：US9745297B2

  公开（公告）日：2017-08-29