1-naphthalen-2-yl-3-[(1R)-1-phenylethyl]urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-naphthalen-2-yl-3-[(1R)-1-phenylethyl]urea
• 化学式: C₁₉H₁₈N₂O
• 分子量: 290.365
• InChiKey: JZLZAKYVXKGSDO-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  R(+)-alpha-甲基苄胺 、 2-萘基异氰酸酯 以25%的产率得到1-naphthalen-2-yl-3-[(1R)-1-phenylethyl]urea
  参考文献：
  名称：

  Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors

  摘要：

  A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or paralmeta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.078

文献信息

• Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
  作者：Sung Hee Hwang、Christophe Morisseau、Zung Do、Bruce D. Hammock

  DOI：10.1016/j.bmcl.2006.08.078

  日期：2006.11

  A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or paralmeta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities. (c) 2006 Elsevier Ltd. All rights reserved.