2,3-ditert-butyl-4H-chromene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,3-ditert-butyl-4H-chromene
• 化学式: C₁₇H₂₄O
• 分子量: 244.37
• InChiKey: ARASGXHWBPGSTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS
  申请人：Jacobio Pharmaceuticals Co., Ltd.

  公开号：US20200392128A1

  公开（公告）日：2020-12-17

  This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.