9-bromo-3-(4-chlorophenyl)-1-phenyl-5H-chromeno[3,4-b]pyridin-5-one | 1414381-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 9-bromo-3-(4-chlorophenyl)-1-phenyl-5H-chromeno[3,4-b]pyridin-5-one
• 英文别名: 9-Bromo-3-(4-chlorophenyl)-1-phenylchromeno[3,4-b]pyridin-5-one；9-bromo-3-(4-chlorophenyl)-1-phenylchromeno[3,4-b]pyridin-5-one
• CAS: 1414381-91-1
• 化学式: C₂₄H₁₃BrClNO₂
• 分子量: 462.73
• InChiKey: GKOJYTDUUDNFDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-bromo-3-aminocoumarin 、 4-氯苯甲醛 、 苯乙炔 在 碘 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以81%的产率得到9-bromo-3-(4-chlorophenyl)-1-phenyl-5H-chromeno[3,4-b]pyridin-5-one
  参考文献：
  名称：

  A simple and expedient synthesis of functionalized pyrido[2,3-c] coumarin derivatives using molecular iodine catalyzed three-component reaction

  摘要：

  A wide variety of substituted pyrido[2,3-c] coumarin derivatives have been accomplished from 3-aminocoumarins, aromatic aldehydes, and alkynes in the presence of 10 mol % molecular iodine in acetonitrile under reflux conditions through one-pot Povarov reactions. Good yields, no need of aqueous work-up procedure and chromatographic separation, environmentally benign are some of the salient features of the present protocol. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.051

文献信息

• A simple and expedient synthesis of functionalized pyrido[2,3-c] coumarin derivatives using molecular iodine catalyzed three-component reaction
  作者：Abu T. Khan、Deb K. Das、Kobirul Islam、Pradipta Das

  DOI：10.1016/j.tetlet.2012.09.051

  日期：2012.11

  A wide variety of substituted pyrido[2,3-c] coumarin derivatives have been accomplished from 3-aminocoumarins, aromatic aldehydes, and alkynes in the presence of 10 mol % molecular iodine in acetonitrile under reflux conditions through one-pot Povarov reactions. Good yields, no need of aqueous work-up procedure and chromatographic separation, environmentally benign are some of the salient features of the present protocol. (C) 2012 Elsevier Ltd. All rights reserved.