5-(1-chloro-3,4-dihydronaphthalen-2-yl)-4-methyl-N,N-di(propan-2-yl)penta-2,4-dienamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(1-chloro-3,4-dihydronaphthalen-2-yl)-4-methyl-N,N-di(propan-2-yl)penta-2,4-dienamide
• 化学式: C₂₂H₂₈ClNO
• 分子量: 357.9
• InChiKey: ZMHWWHZKTYQALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL EFFLUX PUMP INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE POMPE D'EFFLUX
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2009110002A1

  公开（公告）日：2009-09-11

  This invention relates to compounds, which are in general potentiators of antiinfeective agents and inhibitors of bacterial efflux pumps in particular. These novel compounds i.e. substituted dihydronaphtalene derivatives and tetralin derivatives and/or their salts are useful against antibiotic-resistant microbial pathogens, for treating microbial infections by reducing the extrusion of a co-administered antimicrobial agent. This invention also provides processes for the preparation of such efflux pump inhibitors and their compositions with anti infective agents and methods for treatment of microbial infections.