2-N-(naphthalen-1-ylmethyl)-5-nitropyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-N-(naphthalen-1-ylmethyl)-5-nitropyrimidine-2,4-diamine
• 化学式: C15H13N5O2
• 分子量: 295.3
• InChiKey: CZGJVIZAFPCNBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• STEM CELL MODULATION II
  申请人：University of Canberra

  公开号：EP3046560A1

  公开（公告）日：2016-07-27
• [EN] STEM CELL MODULATION II<br/>[FR] MODULATION DE CELLULES SOUCHES
  申请人：UNIV CANBERRA

  公开号：WO2015039187A1

  公开（公告）日：2015-03-26

  Disclosed are methods and compositions for modulating cancer stem cells. More particularly, the present invention discloses the use of protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including metastatic cancer and/or for preventing cancer recurrence.