3-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3H-benzofuran-2-one | 139061-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3H-benzofuran-2-one
• 英文别名: (3Z)-3-(pyridin-4-ylmethylidene)-1-benzofuran-2-one
• CAS: 139061-44-2
• 化学式: C₁₄H₉NO₂
• 分子量: 223.231
• InChiKey: YTSDHSIJDQAMNQ-XFXZXTDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 苯并呋喃-2(3H)-酮 以 乙醇 为溶剂， 反应 72.0h， 以10%的产率得到3-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3H-benzofuran-2-one
  参考文献：
  名称：

  About the Synthesis of Heterocyclic Analogues of Marginalin and Their Transformation Products

  摘要：

  Pyridine-2 or 4-carboxaldehyde, furan-2-aldehyde, were condensed on 2-coumaranone and on 5-hydroxy 2-coumaranone to give new ene-lactones analogues of the natural marginalin. Only the addition compounds issued from 2-coumaranone could give stilbene methyl esters and no rearrangement into benzo [b] furan carboxylates could be observed. These observations are discussed in relation with previous results in the series.

  DOI：

  10.1080/00397919108021591

文献信息

• About the Synthesis of Heterocyclic Analogues of Marginalin and Their Transformation Products
  作者：Michel Barbier

  DOI：10.1080/00397919108021591

  日期：1991.12

  Pyridine-2 or 4-carboxaldehyde, furan-2-aldehyde, were condensed on 2-coumaranone and on 5-hydroxy 2-coumaranone to give new ene-lactones analogues of the natural marginalin. Only the addition compounds issued from 2-coumaranone could give stilbene methyl esters and no rearrangement into benzo [b] furan carboxylates could be observed. These observations are discussed in relation with previous results in the series.