naphthalene-2,6-disulfinic acid | 721917-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphthalene-2,6-disulfinic acid
• 英文别名: Naphthalin-2,6-disulfinsaeure
• CAS: 721917-01-7
• 化学式: C₁₀H₈O₄S₂
• 分子量: 256.303
• InChiKey: GWDFUNAAGQQTCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  naphthalene-2,6-disulfinic acid 在 氢氧化钾 作用下， 生成 2,6-bis-(2,5-dimethoxy-benzenesulfonyl)-naphthalene
  参考文献：
  名称：

  Janczewski; Prajer, Roczniki Chemii, 1955, vol. 29, p. 343,352

  摘要：

  DOI：

文献信息

• Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo
  作者：Suneet Agarwal、Orly Avni、Anjana Rao

  DOI：10.1016/s1074-7613(00)80215-0

  日期：2000.6

  By DNase I hypersensitivity analysis, we have identified an inducible, cyclosporin A-sensitive enhancer located 3' of the interleukin-4 (IL-4) gene. The enhancer binds the Th2-specific transcription factor GATA3 in vivo but is not perceptibly influenced by the absence of a second Th2-specific factor, cMaf. The antigen-inducible transcription factor NFAT1 binds the IL-4 enhancer and the IL-4 promoter only in stimulated Th2 cells; conversely, NFAT1 binds to the interferon (IFN)-gamma promoter only in stimulated Th1 cells. Our results support a model whereby transcription factors such as NFAT1, which are nonselectively induced in antigen-stimulated T cells, gain access to cytokine regulatory regions only in the appropriate subset of differentiated T cells in vivo. This restricted access enables antigen-dependent and subset-specific transcription of cytokine genes.
• Janczewski; Prajer, Roczniki Chemii, 1955, vol. 29, p. 1135
  作者：Janczewski、Prajer

  DOI：——

  日期：——
• Janczewski; Prajer, Roczniki Chemii, 1955, vol. 29, p. 343,352
  作者：Janczewski、Prajer

  DOI：——

  日期：——