N-萘-1-基-1,3-恶唑-2-胺 | 100381-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-萘-1-基-1,3-恶唑-2-胺
• 英文名称: 2-α-Naphthylamino-oxazol
• 英文别名: naphthalen-1-yl-oxazol-2-yl-amine；N-(2-Oxazolyl)-1-naphthylamine；N-naphthalen-1-yl-1,3-oxazol-2-amine
• CAS: 100381-97-3
• 化学式: C₁₃H₁₀N₂O
• 分子量: 210.235
• InChiKey: QPVKBSBPGROOBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-萘基脲 、 溴乙醛 以 水 为溶剂， 反应 1.0h， 生成 N-萘-1-基-1,3-恶唑-2-胺
  参考文献：
  名称：

  Najer,H. et al., Bulletin de la Societe Chimique de France, 1960, p. 2052 - 2061

  摘要：

  DOI：

文献信息

• 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS
  申请人：Pharmagene Laboratories Ltd

  公开号：EP1474140A1

  公开（公告）日：2004-11-10
• [EN] 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS<br/>[FR] 2-OXAZOLAMINES ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR 5-HT2B
  申请人：PHARMAGENE LAB LTD

  公开号：WO2003068226A1

  公开（公告）日：2003-08-21

  The present invention relates to compounds of formula (I): wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either:(i) independently selected from H, R, R', SO2R, C(=O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.