2-(azidomethyl)-6-fluoro-8-(2-methoxyphenyl)-3,4-dihydro-2H-chromene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(azidomethyl)-6-fluoro-8-(2-methoxyphenyl)-3,4-dihydro-2H-chromene
• 化学式: C17H16FN3O2
• 分子量: 313.33
• InChiKey: FMOMJBAEHJRDIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF
  申请人：Heffernan Gavin David

  公开号：US20080182891A1

  公开（公告）日：2008-07-31

  Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R 1 , R 2 , R 3 , R 4 , y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

  提供公式I或其药学上可接受的盐的化合物：其中R1、R2、R3、R4、y、m、n和Ar的定义如下，并在本文的类别和子类别中描述，这些化合物是大脑血清素2C亚型的激动剂或部分激动剂。这些化合物和含有这些化合物的组合物可用于治疗多种中枢神经系统疾病，如精神分裂症。
• Chromane and chromene derivatives and uses thereof
  申请人：Heffernan David Gavin

  公开号：US20060258714A1

  公开（公告）日：2006-11-16

  Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R 1 , R 2 , R 3 , R 4 , y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

  提供化学式I或其药物可接受的盐的化合物：其中R1、R2、R3、R4、y、m、n和Ar均如所定义，并在此处描述的类别和子类别中，这些化合物是2C亚型脑血清素受体的激动剂或部分激动剂。这些化合物和含有这些化合物的组合物可用于治疗多种中枢神经系统疾病，如精神分裂症。
• US7365095B2
  申请人：——

  公开号：US7365095B2

  公开（公告）日：2008-04-29