1-Benzyl-3-[5-(nitrosomethyl)furan-2-yl]indazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-Benzyl-3-[5-(nitrosomethyl)furan-2-yl]indazole
• 英文别名: 1-benzyl-3-[5-(nitrosomethyl)furan-2-yl]indazole
• 化学式: C₁₉H₁₅N₃O₂
• 分子量: 317.3
• InChiKey: WZBBHHNBWVOKIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] USE OF NEP INHIBITORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DISORDERS<br/>[FR] UTILISATION D'INHIBITEURS DE NEP POUR LE TRAITEMENT DE TROUBLES DU SPHINCTER GASTRO-INTESTINAL
  申请人：[en]CURTAILS LLC

  公开号：WO2022265984A1

  公开（公告）日：2022-12-22

  The present disclosure relates to methods, uses, pharmaceutical compositions and kits comprising an NEP inhibitor or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of a gastrointestinal sphincter disorder. Gastrointestinal sphincter disorders include, but are not limited to, achalasia and other hypertensive or spastic sphincter disorders elsewhere in the gastrointestinal tract or sphincter spasms, or hypertensive sphincter disorders of the gastrointestinal tract.