萘-1-磺酸水合物 | 6036-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 萘-1-磺酸水合物
• 英文名称: Naphthalene-1-sulfonic acid hydrate
• 英文别名: naphthalene-1-sulfonic acid;hydrate
• CAS: 6036-48-2
• 化学式: C10H10O4S
• 分子量: 226.25
• InChiKey: DCNHVBSAFCNMBK-UHFFFAOYSA-N

物化性质

• 熔点：
  89-91℃(dried)
• 稳定性/保质期：

  在常温常压下保持稳定

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 海关编码：
  2915900090

制备方法与用途

制备方法

由萘经氯磺酸磺化而得。磺化反应以邻硝基乙苯为溶剂，将萘、氯磺酸和邻硝基乙苯按摩尔比1:1.1:3配合，在0-5℃下进行磺化反应，从而获得纯度为97%的1-萘磺酸。

若采用98%硫酸作磺化剂，则反应温度提高至0-40℃，得到的磺化物含1-萘磺酸83-85%，2-萘磺酸15-17%。加入镁盐或钠盐后，可以将析出的2-萘磺酸的镁盐或钠盐滤除。

接着，含游离1-萘磺酸的滤液经过浓缩、冷却、结晶、过滤、水洗和干燥等步骤，最终得到成品。

用途简介

1-萘磺酸主要用于制造1-萘酚、1-萘酚磺酸及1-萘胺磺酸等中间体。

文献信息

• Production process for product of dehydration reaction and apparatus used for the production
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：US20020099165A1

  公开（公告）日：2002-07-25

  It is an object of the present invention to provide a production method of a dehydration reaction product by which the occurrence of troubles in the production step or the degradation in performance characteristics or quality of various chemical products can be suppressed to a satisfactory extent. A production method of a dehydration reaction product which comprises a dehydration reaction step of subjecting a reaction solution containing a polymerizable compound to the dehydration reaction, said dehydration reaction step comprising using a dehydration reaction apparatus, said dehydration reaction apparatus comprising a reaction vessel, a condenser and a connecting pipe joining said reaction vessel with said condenser and satisfying the requirement: 0.05<( B 3 /A )<35 where A is a capacity (m 3 ) of said reaction vessel and B is a total length (m) of said connecting pipe on the horizontal basis.

  本发明的目的是提供一种脱水反应产物的生产方法，通过该方法可以在生产步骤中抑制各种化学产品的性能特征或质量的降解至满意的程度。 一种脱水反应产物的生产方法，包括将含有可聚合化合物的反应溶液经过脱水反应步骤进行脱水反应，所述脱水反应步骤包括使用脱水反应设备，所述脱水反应设备包括反应容器、冷凝器和连接管道，连接管道将反应容器与冷凝器连接，并满足要求：0.05 < (B3 / A) < 35，其中A是反应容器的容量（m3），B是连接管道的水平总长度（m）。
• Biologically active ketone derivative, preparation and use
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0118036A1

  公开（公告）日：1984-09-12

  2-tert-Butylamino-3'-chloropropiophenone maleate, its preparation, pharmaceutical compositions containing it and their preparation, and its use in therapy, for example the treatment of depression in man.

  马来酸 2-叔丁基氨基-3'-氯苯丙酮、其制剂、含有该物质的药物组合物及其制剂，以及其在治疗中的用途，例如治疗人类抑郁症。
• Method for production of esterified product
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP0989108A2

  公开（公告）日：2000-03-29

  A method for the production of an esterified product is provided which affords an esterified product with high quality by repressing, during the esterification reaction of an alcohol with (meth)acrylic acid, the occurrence of impurities, particularly gel, to be formed owing to the polymerization of the alcohol and the (meth)acrylic acid as raw materials, the esterified product consequently formed, or the mixture thereof. Specifically, a method for the production of an esterified product of this invention comprises esterifying an alcohol represented by the following formula (1):         R1O(R2O)nH     (1) wherein R1 represents a hydrocarbon group of 1 to 30 carbon atoms, R2O represents an oxyalkylene group of 2 to 18 carbon atoms, providing that the repeating units, R2O, may be the same or different and that when the R2O's are in the form of a mixture of two or more species, the repeating units, R2O, may be added either in a block form or in a random form, and n represents an average addition mol number of oxyalkylene groups and is in the range of 0 to 300, with (meth)acrylic acid in a dehydrating solvent in the presence of an acid catalyst and a polymerization inhibitor, wherein a reaction temperature during the esterification reaction is not higher than 130 °C and a circulation speed of the solvent during the esterification reaction is not less than 0.5 cycle/hour.

  本发明提供了一种酯化产品的生产方法，该方法在醇和（甲基）丙烯酸的酯化反应过程中，抑制由于作为原料的醇和（甲基）丙烯酸的聚合反应而形成的杂质（特别是凝胶）的出现，从而提供高质量的酯化产品、由此形成的酯化产品或其混合物。具体来说，生产本发明酯化产品的方法包括将下式（1）所代表的醇酯化： R1O(R2O)nH (1) 其中 R1 代表 1 至 30 个碳原子的烃基，R2O 代表 2 至 18 个碳原子的氧亚烷基，但重复单元 R2O 可以相同或不同，当 R2O 以两种或两种以上混合物的形式存在时，重复单元 R2O 可以块状或无规形式加入、和 n 代表氧亚烷基的平均添加摩尔数，其范围在 0 至 300 之间，在酸催化剂和聚合抑制剂存在下，在脱水溶剂中用（甲基）丙烯酸进行酯化反应，其中酯化反应期间的反应温度不高于 130℃，酯化反应期间溶剂的循环速度不低于 0.5 周期/小时。
• Method for production of esterified product and apparatus therefor
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0989109A1

  公开（公告）日：2000-03-29

  A method for the production of an esterified product which can prevent the occurrence of a gel-like substance during the separation and removal of the water formed by the reaction in the esterification reaction or during the expulsion of a dehydrating solvent by distillation after the esterification reaction by causing an antigelling agent to act on the distillate and consequently permits efficient production of the esterified product of high quality, and an apparatus therefor are to be provided. To be specific, a method for the production of an esterified product of this invention relates to a method for the production of an esterified product by the esterification reaction of an alcohol represented by the following formula (1):         R1O(R2O)nH     (1) wherein R1 represents a hydrocarbon group of 1 to 30 carbon atoms, R2O represents an oxyalkylene group of 2 to 18 carbon atoms, providing that the repeating units, R2O, may be the same or different and that when the R2O's are in the form of a mixture of two or more species, the repeating units, R2O, may be added either in a block form or in a random form, and n represents an average addition mol number of oxyalkylene groups and is in the range of 0 to 300, with (meth)acrylic acid, wherein said method comprises acting an antigelling agent on a distillate.

  本发明将提供一种酯化产品的生产方法，该方法通过使抗凝剂作用于蒸馏物，可防止在酯化反应中分离和去除反应生成的水或在酯化反应后通过蒸馏排出脱水溶剂时出现凝胶状物质，从而可高效生产出高质量的酯化产品，还将提供一种用于该方法的装置。具体而言，本发明的酯化产品生产方法涉及一种通过下式（1）所代表的醇的酯化反应生产酯化产品的方法： R1O(R2O)nH (1) 其中 R1 代表 1 至 30 个碳原子的烃基，R2O 代表 2 至 18 个碳原子的氧亚烷基，但重复单元 R2O 可以相同或不同，当 R2O 以两种或两种以上混合物的形式存在时、重复单元 R2O 可以块状或无规形式添加，n 代表氧亚烷基的平均添加摩尔数，范围在 0 至 300 之间。
• Process and apparatus for producing a dehydration reaction product
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1208910A2

  公开（公告）日：2002-05-29

  It is an object of the present invention to provide a production method of a dehydration reaction product by which the occurrence of troubles in the production step or the degradation in performance characteristics or quality of various chemical products can be suppressed to a satisfactory extent. A production method of a dehydration reaction product    which comprises a dehydration reaction step of subjecting a reaction solution containing a polymerizable compound to the dehydration reaction, said dehydration reaction step comprising using a dehydration reaction apparatus, said dehydration reaction apparatus comprising a reaction vessel, a condenser and a connecting pipe joining said reaction vessel with said condenser and    satisfying the requirement:0.05 < (B3/A) <35 where A is a capacity (m3) of said reaction vessel and B is a total length (m) of said connecting pipe on the horizontal basis.

  本发明的目的是提供一种脱水反应产物的生产方法，通过这种方法可以在令人满意的程度上抑制生产步骤中出现的故障或各种化学产品性能特征或质量的下降。 一种脱水反应产物的生产方法 其中包括一个脱水反应步骤，即将含有可聚合化合物的反应溶液进行脱水反应、 所述脱水反应步骤包括使用脱水反应装置、 所述脱水反应装置包括一个反应容器、一个冷凝器和一个连接所述反应容器和所述冷凝器的连接管，并且 满足以下要求：0.05 < (B3/A) <35 其中，A 为所述反应容器的容量（立方米），B 为所述连接管的水平总长度（米）。