dimethyl (6,8-dichloro-2-hydroxy-2H-chromene)-2,3-dicarboxylate | 64657-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: dimethyl (6,8-dichloro-2-hydroxy-2H-chromene)-2,3-dicarboxylate
• 英文别名: 2,3-Dicarboxymethoxy-6,8-dichloro-chrom-3-en-2ol；2,3-Dicarbomethoxy-6,8-dichlorchrom-3-en-2-ol；2.3-Dicarbomethoxy-6.8-dichloro-chrom-3-en-2-ol；Dimethyl 6,8-dichloro-2-hydroxychromene-2,3-dicarboxylate
• CAS: 64657-45-0
• 化学式: C₁₃H₁₀Cl₂O₆
• 分子量: 333.125
• InChiKey: LZLRSHWSKYSSQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丁炔二酸二甲酯 、 3,5-二氯水杨醛 在 哌啶 、 iron(III) chloride 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以79%的产率得到dimethyl (6,8-dichloro-2-hydroxy-2H-chromene)-2,3-dicarboxylate
  参考文献：
  名称：

  An efficient route to coumarin derivatives under dual catalysis, an organo- and a Lewis acid catalyst

  摘要：

  An efficient reaction of dialkyl acetylenedicarboxylate with various o-hydroxy aromatic aldehydes under dual catalysis with piperidine and FeCl3 in refluxing toluene afforded alkyl 2-oxo-2-(2-oxo-2H-chromen-3-yl) acetates in good to excellent yield. The advantages of this reaction include the use of easily available starting materials, one-pot reaction, mild reaction conditions and operational simplicity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.092

文献信息

• GUPTA R. K.; GEORGE M. V., INDIAN J. CHEM., 1977, B15, NO 3,
  作者：GUPTA R. K.、 GEORGE M. V.

  DOI：——

  日期：——
• An efficient route to coumarin derivatives under dual catalysis, an organo- and a Lewis acid catalyst
  作者：Gourhari Maiti、Rajiv Karmakar、Utpal Kayal、Rudraksha Nath Bhattacharya

  DOI：10.1016/j.tet.2012.07.092

  日期：2012.10

  An efficient reaction of dialkyl acetylenedicarboxylate with various o-hydroxy aromatic aldehydes under dual catalysis with piperidine and FeCl3 in refluxing toluene afforded alkyl 2-oxo-2-(2-oxo-2H-chromen-3-yl) acetates in good to excellent yield. The advantages of this reaction include the use of easily available starting materials, one-pot reaction, mild reaction conditions and operational simplicity. (C) 2012 Elsevier Ltd. All rights reserved.