P(O)(O2C20H12)(NHCH2-4-OMeC6H4) | 1313031-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: P(O)(O2C20H12)(NHCH2-4-OMeC6H4)
• 英文别名: N-[(4-methoxyphenyl)methyl]-13-oxido-12,14-dioxa-13-phosphoniapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-amine
• CAS: 1313031-66-1
• 化学式: C₂₈H₂₂NO₄P
• 分子量: 467.461
• InChiKey: FQHVHSWAYAZOJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,1'-binaphthyl-2,2'-diyl phosphorochloridate 、 4-甲氧基苄胺 以 二氯甲烷 为溶剂， 反应 2.5h， 以310 mg的产率得到P(O)(O2C20H12)(NHCH2-4-OMeC6H4)
  参考文献：
  名称：

  Phosphoroamidate compounds of 1,1′-Bi-2-napthol: Synthesis, structural characterization and solvent-free ring-opening polymerization of ε-caprolactone and l-lactide

  摘要：

  New phosphoroamidate compounds with 1,1'-Bi-2-napthol (binol) ligand were synthesized from the corresponding phosphorochloridate intermediates and benzyl amine or benzyl amine derivatives. They were completely characterized using different spectroscopic methods and single crystal X-ray diffraction studies. These compounds effectively catalyze the ring-opening polymerization of epsilon-caprolactone (CL) and L-lactide (LA). This methodology of polymer synthesis is green and environmental benign since phosphorus is a natural constituent of human anatomy and these polymers being completely biodegradable. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.01.088

文献信息

• Tf2O-Mediated P(O)–N Bond Formation of Either P(O)–OH or P(O)–H Reagents with Multitype Amines
  作者：Da-Wei Shi、Hui-Qi Yue、Ming Li、Jie Liu、Chang-Cheng Wang、Shang-Dong Yang、Bin Yang

  DOI：10.1021/acs.joc.3c02970

  日期：2024.5.17

  a Tf2O-mediated approach for the direct amination of either P(O)–OH or P(O)–H reagents with a variety of aliphatic or aromatic amines. Without the requirement of precious metals and toxic reagents, this protocol provides an alternative route to various phosphinamides and phosphoramides. The reaction proceeds under simple and mild conditions and can be effectively scaled up with similar efficiency.

  我们开发了一种 Tf 2 O 介导的方法，用于将 P(O)–OH 或 P(O)–H 试剂与各种脂肪族或芳香族胺直接胺化。该方案不需要贵金属和有毒试剂，为各种膦酰胺和磷酰胺提供了替代途径。该反应在简单温和的条件下进行，并且可以以类似的效率有效地扩大规模。