[2-(3',6'-Dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-yl)phenyl]-naphthalen-1-ylsulfamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [2-(3',6'-Dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-yl)phenyl]-naphthalen-1-ylsulfamic acid
• 英文别名: [2-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4-yl)phenyl]-naphthalen-1-ylsulfamic acid
• 化学式: C₃₆H₂₃NO₈S
• 分子量: 629.6
• InChiKey: SRBPIAHFJJYHJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  46
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] MYELOPEROXIDASE IMAGING AGENTS<br/>[FR] AGENTS D'IMAGERIE DE MYÉLOPEROXYDASE
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2018094005A1

  公开（公告）日：2018-05-24

  Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using positron emission tomography or fluorescence imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using radiolabeled and unlabeled compounds are also provided.

  本文提供了作为成像剂有用的化合物。本文提供的示例化合物可用作髓过氧化物酶成像剂，使用正电子发射断层扫描或荧光成像技术。还提供了制备本文提供的化合物的方法以及使用放射标记和未标记化合物的诊断方法。
• Myeloperoxidase imaging agents
  申请人：The General Hospital Corporation

  公开号：US11352326B2

  公开（公告）日：2022-06-07

  Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using positron emission tomography or fluorescence imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using radiolabeled and unlabeled compounds are also provided.

  本文提供的化合物可用作成像剂。本文提供的示例化合物可用作使用正电子发射断层扫描或荧光成像技术的髓过氧化物酶成像剂。还提供了制备本文所提供化合物的方法以及使用放射性标记和未标记化合物的诊断方法。
• MYELOPEROXIDASE IMAGING AGENTS
  申请人：The General Hospital Corporation

  公开号：EP3541431A1

  公开（公告）日：2019-09-25
• PROFILING REACTIVE OXYGEN, NITROGEN AND HALOGEN SPECIES
  申请人：ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC

  公开号：US20170122954A1

  公开（公告）日：2017-05-04

  Provided are methods, kits and systems for simultaneously profiling of global reactive species and selected reactive species, such as global and specific reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive halogen species (RHS) or combinations thereof through multiplexed fluorescence detection of three or more compatible indicator probes in live cells or subcellular organelles.
• Myeloperoxidase Imaging Agents
  申请人：The General Hospital Corporation

  公开号：US20190315689A1

  公开（公告）日：2019-10-17

  Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using positron emission tomography or fluorescence imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using radiolabeled and unlabeled compounds are also provided.