1,3-bis-(4-phenyl-piperazino)-propane | 102753-90-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,3-bis-(4-phenyl-piperazino)-propane
• 英文别名: 1,3-Bis-(4-phenyl-piperazino)-propan；1,3-Bis(4-phenyl-1-piperazinyl)propane；1-phenyl-4-[3-(4-phenylpiperazin-1-yl)propyl]piperazine
• CAS: 102753-90-2
• 化学式: C₂₃H₃₂N₄
• 分子量: 364.534
• InChiKey: XCGHXCKEXCDSKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  13
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 、 1-溴-3-氯丙烷 在 乙醇 、 sodium carbonate 作用下， 生成 1,3-bis-(4-phenyl-piperazino)-propane
  参考文献：
  名称：

  Derivatives of Piperazine. XXXIV. Some Reactions of Trimethylene Chlorobromide with 1-Arylpiperazines

  摘要：

  DOI：

  10.1021/jo01088a009

文献信息

• Muscarinic M1 receptor agonists for pain management
  申请人：Davis E. Robert

  公开号：US20050130961A1

  公开（公告）日：2005-06-16

  Disclosed herein are compounds and methods for treating chronic neuropathic pain. It has been discovered that compounds that selectively interact with a muscarinic receptor subtype are effective in treating neuropathic pain. Specifically, compounds that selectively interact with the M1 muscarinic receptor subtype may be used.

  本文公开了治疗慢性神经病性疼痛的化合物和方法。发现选择性与毒蕈碱受体亚型相互作用的化合物对治疗神经病性疼痛有效。具体而言，可使用选择性与M1毒蕈碱受体亚型相互作用的化合物。
• Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT 1A serotonin receptor ligands
  作者：Giuseppe Caliendo、Ferdinando Fiorino、Paolo Grieco、Elisa Perissutti、Vincenzo Santagada、Beatrice Severino、Giancarlo Bruni、Maria Rosaria Romeo

  DOI：10.1016/s0968-0896(00)00004-3

  日期：2000.3

  A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT1A receptor, some of which were selective with respect 5-HT2A and 5-HT2C receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D-1, D-2 dopaminergic and alpha(1)-, alpha(2)-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT1A sites with subnanomolar affinity (IC50 = 0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. (C) 2000 Elsevier Science Ltd. All rights reserved.
• 2-{4-[3-(4-Aryl/heteroaryl-1-piperazinyl)propoxy]phenyl}-2H-benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors
  作者：Anna Sparatore、Mara Goegan、Alfredo Cagnotto、Fabio Sparatore

  DOI：10.1016/s0014-827x(99)00046-4

  日期：1999.6

  A small set of 2-4-[3-(4-aryl/heteroaryl-piperazinyl)propoxy]phenyl}-2H-benzotriazoles and corresponding N-oxides were prepared. The synthesized compounds were able to bind on some serotonin (5-HT1A, 5-HT2A) and dopamine (D-2, D-3) receptors, while displaying poor or no affinity for 5-HT1B, 5-NT2C, 5-HT3, and 5-HT4 subtypes. The strong contribution of the N-oxide function for the binding on 5-HT1A, D-2 and D-3 receptors is noteworthy. For 2-4-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]phenyl}-2H-benzotriazol-1-oxide (4b), the binding constants (K-i) were 11.9 (5-HT1A) and 10.5 nM (D-3). In a general pharmacological screening, the 2-4-[3-(4-phenyl-1-piperazinyl)propoxy]phenyl}-2H-benzotriazole (3a) exhibited only very weak activities, with the exception of protecting mice from cyanide-induced hypoxia. (C) 1999 Elsevier Science S.A. All rights reserved.
• EP1613321A2
  申请人：——

  公开号：EP1613321A2

  公开（公告）日：2006-01-11
• [EN] MUSCARINIC M1 RECEPTOR AGONISTS FOR PAIN MANAGEMENT<br/>[FR] TRAITEMENT DE LA DOULEUR AU MOYEN D'AGONISTES DU RECEPTEUR MUSCARINIQUE M1
  申请人：ACADIA PHARM INC

  公开号：WO2004087158A2

  公开（公告）日：2004-10-14

  Disclosed herein are compounds and methods for treating chronic neuropathic pain. It has been discovered that compounds that selectively interact with a muscarinic receptor subtype are effective in treating neuropathic pain. Specifically, compounds that selectively interact with the M1 muscarinic receptor subtype may be used.