Aeroplysinin-2 | 37694-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: Aeroplysinin-2
• 英文别名: (3aS,7aR)-5,7-dibromo-3a-hydroxy-6-methoxy-3,7a-dihydro-1-benzofuran-2-one
• CAS: 37694-12-5
• 化学式: C₉H₈Br₂O₄
• 分子量: 339.968
• InChiKey: ZIWGLWRAFFMGTG-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  、 乙酸酐 在 吡啶 作用下， 反应 44.0h， 生成 Aeroplysinin-2 、 aeroplysinin-2 acetate
  参考文献：
  名称：

  Dibromotyrosine derivatives from the ethanol extract of the marine sponge Aplysina sp.: structures, transformations, and origin

  摘要：

  从海洋海绵（中国南海）的乙醇提取物中分离出29种3,5-二溴酪氨酸衍生物，包括之前未知的化合物，特别是对羟基环己二烯酮和对羟基环己烯酮缩酮。分离出的烯酮、二烯酮和缩酮可能是气生菌素-1与水和醇反应过程中的转化产物。

  DOI：

  10.1007/s11172-011-0088-9

文献信息

• Marine Compounds with Calcium Channel Blocking Properties for the Treatment of Cognitive or Neurodegenerative Diseases
  申请人：Gil Ana Martinez

  公开号：US20080039513A1

  公开（公告）日：2008-02-14

  The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia . The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.
• [EN] MARINE COMPOUNDS WITH CALCIUM CHANNEL BLOCKING PROPERTIES FOR THE TREATMENT OF COGNITIVE OR NEURODEGENERATIVE DISEASES<br/>[FR] COMPOSES MARINS POSSEDANT DES PROPRIETES BLOQUANT LES CANAUX CALCIQUES, DESTINES AU TRAITEMENT DE MALADIES COGNITIVES OU NEURODEGENERATIVES
  申请人：NEUROPHARMA SA

  公开号：WO2005123073A1

  公开（公告）日：2005-12-29

  The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia. The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.
• Dibromotyrosine derivatives from the ethanol extract of the marine sponge Aplysina sp.: structures, transformations, and origin
  作者：E. A. Santalova、V. A. Denisenko、V. P. Glazunov、A. I. Kalinovskii、S. D. Anastyuk、V. A. Stonik

  DOI：10.1007/s11172-011-0088-9

  日期：2011.3

  Twenty nine 3,5-dibromotyrosine derivatives were isolated from the ethanol extract of the marine sponge Aplysina sp. (South China Sea) including the earlier unknown compounds, in particular, p-hydroxycyclohexadienone and p-hydroxycyclohexenone ketals. The isolated enones, dienones, and ketals can be transformation products of aeroplysinin-1 in the course of its reactions with water and alcohols.

  从海洋海绵（中国南海）的乙醇提取物中分离出29种3,5-二溴酪氨酸衍生物，包括之前未知的化合物，特别是对羟基环己二烯酮和对羟基环己烯酮缩酮。分离出的烯酮、二烯酮和缩酮可能是气生菌素-1与水和醇反应过程中的转化产物。