ML-9 free base | 110448-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ML-9 free base
• 英文别名: 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane
• CAS: 110448-31-2
• 化学式: C₁₅H₁₇ClN₂O₂S
• 分子量: 324.8
• InChiKey: OZSMSRIUUDGTEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Methods and compositions for preventing vasospasm
  申请人：Vinten-Johansen Jakob

  公开号：US20060079573A1

  公开（公告）日：2006-04-13

  Methods and compositions for preventing or reducing vascular smooth muscle contraction are provided. Exemplary compositions comprise an MLCK inhibitor, for example wortmannin, in an amount effective to prevent or reduce vascular smooth muscle vasospams by about 90% for at least about 20 minutes. Methods for identifying other modulators of MLCK are also provided.

  提供了防止或减少血管平滑肌收缩的方法和组合物。示例性组合物包含一种 MLCK 抑制剂，例如沃特曼宁，其有效量可在至少约 20 分钟内防止或减少血管平滑肌收缩约 90%。还提供了鉴定 MLCK 其他调节剂的方法。
• Small molecules that reduce fungal growth
  申请人：Johnson I. Douglas

  公开号：US20060194769A1

  公开（公告）日：2006-08-31

  The present invention relates to methods for reducing the growth of a fungus with an anti-fungal small molecule. Methods for reducing fungal cell growth in a subject with an anti-fungal small molecule and related compositions are provided. Topical lotion formulations of an anti-fungal small molecule and a topical carrier are also provided.

  本发明涉及用抗真菌小分子减少真菌生长的方法。本发明提供了用抗真菌小分子和相关组合物减少受试者体内真菌细胞生长的方法。还提供了抗真菌小分子和局部载体的局部洗剂配方。
• METHOD FOR PREVENTING HAIR LOSS
  申请人：Icahn School of Medicine at Mount Sinai

  公开号：EP3993764A1

  公开（公告）日：2022-05-11
• HIGH THROUGHPUT ASSAY FOR HUMAN RHO KINASE ACTIVITY WITH ENHANCED SIGNAL-TO-NOISE RATIO
  申请人：Sharif A. Najam

  公开号：US20080096238A1

  公开（公告）日：2008-04-24

  The present invention provides a high throughput assay with increased signal-to-noise ration for human Rho kinase activity in vitro, and methods and kits therefor. A high throughput method of assaying a test compound for human Rho kinase modulating activity is also provided.