N-(6-aminohexyl)-5-chloronaphthalene-2-sulfonamide | 84215-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(6-aminohexyl)-5-chloronaphthalene-2-sulfonamide
• CAS: 84215-10-1
• 化学式: C₁₆H₂₁ClN₂O₂S
• 分子量: 340.9
• InChiKey: WAEIMOCPASQBSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy
  申请人：Singh Chandra U.

  公开号：US20130189354A1

  公开（公告）日：2013-07-25

  The present invention relates to compositions and methods for treating pain wherein the compositions comprise a combination of tramadol or a pharmaceutically acceptable salt thereof, magnesium or a pharmaceutically acceptable salt thereof; and gabapentin or pregabalin. The therapeutic combination can further contain capsaicin or an ester of capsaicin.

  本发明涉及用于治疗疼痛的组合物和方法，其中所述组合物包括曲马多或其药学上可接受的盐、镁或其药学上可接受的盐；以及加巴嘌醇或普瑞巴林。治疗组合物还可以包含辣椒素或辣椒素酯。
• PHARAMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY
  申请人：Singh Chandra Ulagaraj

  公开号：US20110039875A1

  公开（公告）日：2011-02-17

  The present invention provides methods and compositions for the treatment of neuropathic pain. In certain embodiments, compositions comprising an dextromethorphan (or other N-methyl-D-aspartate receptor antagonist), tramadol, and gabapentin can synergistically act to reduce pain in a human patient. Pharmaceutical compositions may also comprise a capsaicinoid, an esterified capsaicinoid, and/or a tricyclic antidepressant.

  本发明提供了治疗神经病痛的方法和组合物。在某些实施例中，含有右美沙芬（或其他N-甲基-D-天门冬氨酸受体拮抗剂）、曲马多和加巴喷丁的组合物可以协同作用于人类患者，以减轻疼痛。药物组合物也可以包括辣椒素类、酯化辣椒素类和/或三环抗抑郁剂。
• Use of calmodulin binding drugs for preventing pregnancy
  申请人：THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：EP0102162A1

  公开（公告）日：1984-03-07

  Certain calmodulin binding drugs are useful as vaginal contraceptives and are preferably provided in the form of a suppository. The active ingredients can be: N-PHENYL-NAPHTHYLAMINE, ANTHROYLCHOLINE, NAPHTHALENESULFONAMIDES, PHENOTHIAZINE SULFOXIDES. One particular calmodulin binding drug can be injected or introduced into the uterus, for instance, with paraffin oil, to prevent preganancy.

  某些钙调蛋白结合药物可用作阴道避孕药，最好以栓剂的形式提供。 活性成分可以是正苯基萘胺、蒽胆碱、萘磺酰胺、吩噻嗪硫化物。 一种特殊的钙调素结合药物可以注射或导入子宫，例如用石蜡油，以防止早孕。
• Inhibiting the development of tolerance to and/or dependence on an additive substance
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：EP0608893A1

  公开（公告）日：1994-08-03

  Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM₁ or GT1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.

  阻断 N-甲基-D-天冬氨酸（NMDA）受体的无毒物质，如右美沙芬或右美沙芬等吗啡烷，或阻断 NMDA 受体激活的一种主要细胞内后果的物质，如神经节苷脂，如 GM₁或 GT1b，三氟拉嗪等吩噻嗪，或 N-(6-氨基己烷基)萘磺酰胺等、 神经节苷脂，如 GM₁或 GT1b；吩噻嗪，如三氟拉嗪；或萘磺酰胺，如 N-（6-氨基己基）-5-氯-1-萘磺酰胺；抑制对成瘾性药物，如吗啡、可待因等麻醉性镇痛药的耐受性和/或依赖性。