Pyrrobutamine phosphate | 135-31-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Pyrrobutamine phosphate
• 英文别名: 1-[4-(4-chlorophenyl)-3-phenylbut-2-enyl]pyrrolidine;phosphoric acid
• CAS: 135-31-9
• 化学式: C20H28ClNO8P2
• 分子量: 507.8
• InChiKey: UAAAHOLLLRWGGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  159
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Medicinal composition and method of making same
  申请人：Tucker, William Gough

  公开号：EP0212875A2

  公开（公告）日：1987-03-04

  There is disclosed a medicinal composition comprising lipid, non-lipid liquid and pharmaceutical ingredients, characterized by the fact that the ingredients are emulsified and encapsulated in a gelatine capsule as a liquid and in a physical form capable of delivering the pharmaceutical in its unaltered original state to the brush layer of the small intestine; the non-lipid ingredient being water, a water substitute not attacked by lipid enzyme activity or a mixture of water substitute and water; and the total water in the emulsion is not more than 20%; the physical form of the ingredients is as follows: (a) the lipid ingredient is in the form of individual globules predominantly of a size less than about 3 microns in diameter; (b) each of the globules contains the pharmaceutical ingredient dispersed therein; and (c) each of the globules is enveloped within a surrounding layer of said non-lipid liquid ingredient adhered to the globule by surface tension, the surrounding layer serving to maintain the globules in independent form and to present only the non-lipid liquid surface to the stomach fluids. There is also disclosed a method of making same.

  本发明公开了一种由脂质、非脂质液体和药物成分组成的药物组合物，其特征在于这些成分被乳化并以液体的物理形式封装在明胶胶囊中，能够以未改变的原始状态将药物输送到小肠刷状层；非脂质成分是水、未被脂质酶活性攻击的水替代物或水替代物和水的混合物；乳化液中的总水分不超过 20%；成分的物理形式如下： (a) 脂质成分主要呈直径小于约 3 微米的单个球状； (b) 每个小球都含有分散在其中的药物成分；以及 (c) 每个球状物都被包在一层非脂质液体成分的周围层中，这层液体成分通过表面张力附着在球状物上，周围层的作用是保持球状物的独立形态，并使胃液只看到非脂质液体表面。 此外，还公开了一种制作方法。
• Composition and method for treatment of symptoms associated with various skin conditions
  申请人：THERACEUTIX, LLC

  公开号：US10624877B2

  公开（公告）日：2020-04-21

  Compositions containing imidazole-based compounds, and optionally, colloidal oatmeal, for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin. Also, methods for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin using compositions containing imidazole-based compounds, and optionally, colloidal oatmeal.

  用于治疗、预防和控制皮肤症状、状况、疾病和失调的含有咪唑类化合物和可选胶体燕麦片的组合物。此外，使用含有咪唑类化合物的组合物和可选的胶体燕麦片治疗、预防和控制皮肤症状、状况、疾病和失调的方法。
• Unit dose of material in system and method
  申请人：——

  公开号：US20020022058A1

  公开（公告）日：2002-02-21

  The invention provides a unit dose of an orally consumable material, having a predetermined pharmaceutically effective amount of at least one nonprescription discomfort reliever and a predetermined nutritionally effective amount of at least one nutritional supplement. Each unit dose may be in a container having indications of the amount discomfort reliever and the amount of nutritional supplement in each unit dose. Instructions are provided for consuming the material for discomfort relief and supplementing nutrition. Consumption of the unit dose simultaneously relieves discomfort and supplements nutrition.

  本发明提供了一种单位剂量的口服材料，其中含有预定药效量的至少一种非处方药不适缓解剂和预定营养有效量的至少一种营养补充剂。每个单位剂量可装在一个容器中，容器上标明每个单位剂量中的不适缓解剂用量和营养补充剂用量。提供了食用该材料以缓解不适和补充营养的说明。服用单位剂量可同时缓解不适和补充营养。
• COMPOSITION AND METHOD FOR TREATMENT OF SYMPTOMS ASSOCIATED WITH VARIOUS SKIN CONDITIONS
  申请人：THERACEUTIX, LLC

  公开号：US20140212362A1

  公开（公告）日：2014-07-31

  Compositions containing imidazole-based compounds, and optionally, colloidal oatmeal, for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin. Also, methods for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin using compositions containing imidazole-based compounds, and optionally, colloidal oatmeal.
• US4269835A
  申请人：——

  公开号：US4269835A

  公开（公告）日：1981-05-26