Ergotamine Tartrate | 379-79-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 英文名称: Ergotamine Tartrate
• 英文别名: (6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;(2R,3R)-2,3-dihydroxybutanedioic acid
• CAS: 379-79-3
• 化学式: C70H76N10O16
• 分子量: 1313.4
• InChiKey: CJMJLDQKTOJACI-BGQAIRJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  96
• 可旋转键数：
  11
• 环数：
  16.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  352
• 氢给体数：
  10
• 氢受体数：
  18

文献信息

• Therapeutic approaches for treating Alzheimer disease and related disorders through a modulation of synapse function
  申请人：Pharnext

  公开号：US10350195B2

  公开（公告）日：2019-07-16

  Compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, disclosed are combined therapies that modulate synapse function for treating the disease.

  治疗阿尔茨海默病及相关疾病的组合物和方法。更具体地说，公开了用于治疗该疾病的调节突触功能的组合疗法。
• NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS
  申请人：Pharnext

  公开号：EP2282778B1

  公开（公告）日：2017-03-08
• NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE
  申请人：Pharnext

  公开号：EP2282779B1

  公开（公告）日：2013-03-13
• COMBINATION COMPOSITIONS FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS WITH ZONISAMIDE AND ACAMPROSATE
  申请人：Pharnext

  公开号：EP2285374B1

  公开（公告）日：2019-09-18
• THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF SYNAPSE FUNCTION
  申请人：Cohen Daniel

  公开号：US20110269764A1

  公开（公告）日：2011-11-03

  The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate synapse function for treating said disease.