Barium(2+);2-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonic acid;2-[(2-oxidonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Barium(2+);2-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonic acid;2-[(2-oxidonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate
• 英文别名: barium(2+);2-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonic acid;2-[(2-oxidonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate
• 化学式: C40H26BaN4O8S2
• 分子量: 892.1
• InChiKey: LFZDEAVRTJKYAF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  9.66
• 重原子数：
  55
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  221
• 氢给体数：
  2
• 氢受体数：
  12

ADMET

毒理性

• 解毒与急救

立即急救：确保已经进行了充分去污。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/钡及其相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Barium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并如有必要进行治疗……预见癫痫发作并如有必要进行治疗……对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……不要尝试中和，因为可能会发生放热反应。在去污染后，用干燥的无菌敷料覆盖皮肤烧伤……/钡和相关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry sterile dressings after decontamination ... . /Barium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于失去意识或严重呼吸困难的病人，考虑进行口咽或鼻咽插管以控制气道。监测心率和必要时治疗心律失常...开始静脉输注0.9%的生理盐水（NS）或乳酸钠林格氏液（LR）/SRP：“保持开放”，最低流量/。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用丙美卡因氢氯化物辅助眼部冲洗...。/钡剂及相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) /SRP: "To keep open", minimal flow rate/. For hypotension with signs of hypovolemia, administer fluid cautiously Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Barium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/对兔子的皮肤刺激：阴性。

/LABORATORY ANIMALS: Acute Exposure/ Skin irritation to rabbits: negative.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：长期暴露或致癌性 / 将250只三周大的奥斯本-门德尔大鼠分为5组，每组50只，每组按性别平均分配，开始进行为期两年的D&C红色10号饲料喂养实验，该颜色混合在饲料中的比例为1%，0.25%，0.05%，0.01%和0%（对照组），并自由采食。该颜色对试验大鼠的生长速率没有明显影响。在两年试验中，通过在饲料中添加色素，大鼠的存活率有所提高。在1%和0.25%喂养水平的大鼠中，注意到脾脏轻微至中度肿大。大体上，42%的大鼠患有肺炎，17%患有肾炎，17%患有垂体病变，43%的雌性大鼠患有乳腺肿瘤。在这250只大鼠中随机分布的其他偶然大体病理包括7只大鼠的淋巴肉瘤，5只雄性的皮下肿瘤，4只雌性的子宫内膜肉瘤，4只大鼠的甲状腺肿瘤，3只的睾丸肿瘤，2只的肝脏肿瘤，1只的腹壁脂肪瘤，1只的白血病，1只的卵巢肿瘤，5只的卵巢囊肿，2只的卵巢脓肿，以及1只大鼠各有脾梗死、大腹部血肿和足垫肉芽肿。从这250只大鼠中准备了大约800个组织切片进行显微镜研究。归因于D&C红色10号毒性的组织病理学仅发生在脾脏和骨髓中。由于试验动物的存活被认为比它们轻微至中度的脾脏和骨髓增生更重要，因此很明显D&C红色10号在这个实验中有益处。然而，由于1%和0.25%喂养水平的脾肿大和骨髓增生的不利副作用，0.05%的水平应被视为“无效果”水平。 / D和C红色10号（2-（2-羟基-1-萘基偶氮）-1-萘磺酸钠的单钠盐） /

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Two hundred and fifty 3-week-old Osborne-Mendel rats divided into 5 groups of 50 rats each, and each group equally divided by sex, were started on a 2-year feeding experiment on D & C Red No. 10 which was mixed into the diet at levels of 1%, 0.25%, 0.05%, 0.01%, and 0% (controls) and fed ad libitum. The color had no apparent effect on the growth rate of test rats. Percentage of rats surviving on the 2-year test was increased by the addition of the color to the diet. Slight to moderate splenic enlargement was noted in 1% and 0.25% feeding level rats. Grossly 42% of the rats had pneumonia, 17% had nephritis, 17% had pituitary lesions, and 43% of the females had mammary tumors. Other incidental gross pathology randomly distributed among these 250 rats included lymphosarcoma in 7 rats, subcutaneous tumors in 5 males, endometrial sarcomas in 4 females, thyroid tumors in 4 rats, testicular tumors in 3, hepatic tumors in 2, abdominal lipoma in 1, leukemia in 1, ovarian tumor in 1, cystic ovaries in 5, ovarian abscesses in 2, and 1 rat each with a splenic infarct, a large abdominal hematoma, and a foot-pad granuloma. Approximately 800 tissue sections from these 250 rats were prepared for microscopic study. Histopathology attributable to D & C Red No. 10 toxicity occurred only in the spleen and bone marrow. Since survival of the test animals is considered to be more important to these animals than their slight to moderate splenic and bone marrow hyperplasia, it is apparent that D & C Red No. 10 had a beneficial effect in this experiment. However, because of the undesirable side effects of splenomegaly and bone-marrow hyperplasia at the 1% and 0.25% feeding levels, the 0.05% level should be considered the "no-effect" level. / D and C Red No. 10 (monosodium salt of 2-(2-hydroxy-1-naphthylazo)-1-naphthalenesulfonic acid)/

来源:Hazardous Substances Data Bank (HSDB)