disodium;7-hydroxy-8-phenyldiazenylnaphthalene-1,3-disulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: disodium;7-hydroxy-8-phenyldiazenylnaphthalene-1,3-disulfonate
• 化学式: C16H10N2Na2O7S2
• 分子量: 452.4
• InChiKey: HSXUHWZMNJHFRV-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.22
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  176
• 氢给体数：
  1
• 氢受体数：
  9

ADMET

代谢

当以500毫克/千克体重的剂量给兔子喂食橙色G染料时，有40%以对氨基酚的形式通过尿液排出，3%以邻氨基酚的形式排出，0.6%以自由苯胺的形式排出……在给予单次口服剂量250毫克/千克体重的老鼠的尿液中，有61%出现对氨基酚，而在粪便中发现了苯胺。无论是在尿液还是粪便中，都没有发现未改变的染料……

OF 500 MG/KG BODY WT ORANGE G FED TO RABBITS, 40% IS EXCRETED IN THE URINE AS PARA-AMINOPHENOL, 3% AS ORTHO-AMINOPHENOL AND 0.6% AS FREE ANILINE... IN THE URINE OF RATS GIVEN SINGLE ORAL DOSES OF 250 MG/KG BODY WT, 61% APPEARS AS PARA-AMINOPHENOL, AND ANILINE IS FOUND IN FECES. NO UNCHANGED DYE IS FOUND IN EITHER THE URINE OR THE FECES...

来源:Hazardous Substances Data Bank (HSDB)

代谢

人体尿液在给予20毫克/千克体重的橙色G后，其中含有95%对氨基酚，0.5%苯胺和1.3%未改变的色素...

THE URINE OF HUMANS GIVEN 20 MG/KG BODY WEIGHT ORANGE G CONTAINED 95% AS PARA-AMINOPHENOL, 0.5% AS ANILINE AND 1.3% AS UNCHANGED COLOR...

来源:Hazardous Substances Data Bank (HSDB)

代谢

橙色G的偶氮键可以通过存在于鼠粪便中的细菌以及鼠肝匀浆还原...

THE AZO LINKAGE OF ORANGE G IS REDUCED BY BACTERIA PRESENT IN RAT FECES AND BY RAT-LIVER HOMOGENATES...

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

没有关于人类的数据。动物致癌性证据不足。总体评估：第3组：该物质对人类致癌性无法分类。

No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌剂：CI 橙色 G

IARC Carcinogenic Agent:CI Orange G

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专论集：第8卷：（1975年）一些芳香偶氮化合物

IARC Monographs:Volume 8: (1975) Some Aromatic Azo Compounds

来源:International Agency for Research on Cancer (IARC)

毒理性

• 非人类毒性摘录

在未指明性别和品系的20只小鼠中，每周服用15-20毫克橙G，持续一生，每周5天，以溶液的形式添加到20克棕色面包中，没有发生肝脏肿瘤。最后一只存活的小鼠在治疗开始后538天死亡...

NO LIVER TUMOR OCCURRED IN A GROUP OF 20 MICE (SEX AND STRAIN UNSPECIFIED) WHICH RECEIVED WEEKLY DOSES OF 15-20 MG ORANGE G FOR LIFE, GIVEN OVER 5 DAYS A WK, IN THE FORM OF A SOLN IN TAP-WATER ADDED TO 20 G BROWN BREAD. THE LAST SURVIVING MOUSE DIED 538 DAYS AFTER THE START OF THE TREATMENT...

来源:Hazardous Substances Data Bank (HSDB)