acridine red

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: acridine red
• 英文别名: Acridine Red 3B；N-methyl-6-methyliminoxanthen-3-amine;hydrochloride
• 化学式: C₁₅H₁₄N₂O*ClH
• 分子量: 274.75
• InChiKey: IVHDZUFNZLETBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.81
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  3

ADMET

毒理性

• 相互作用

T4 光灭活在与阿克哩啶红一起孵化后被观察到。这种灭活遵循单次击中动力学，与辐射时间有关。

T4 PHOTOINACTIVATION WAS OBSERVED AFTER INCUBATION WITH ACRIDINE RED. THE INACTIVATION FOLLOWED SINGLE HIT KINETICS AS A FUNCTION OF THE IRRADIATION TIME.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

对兔眼有中等伤害。

MODERATELY INJURIOUS TO RABBIT EYES.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

氯化acriflavin在10-6-10-5M浓度下，通过50%抑制外源8-3H标记AMP向无红细胞疟原虫RNA的掺入。与氯化acriflavin相比，acriflavin orange和acriflavin red的效力分别低10倍和100倍。

ACRIFLAVINE HYDROCHLORIDE, AT 10-6-10-5M, INHIBITED BY 50% INCORPORATION OF RADIOACTIVITY FROM EXOGENOUS 8-3H-LABELED AMP INTO RNA OF ERYTHROCYTE-FREE MALARIAL PARASITES. ACRIDINE ORANGE & ACRIDINE RED WERE 10- & 100-FOLD LESS POTENT, RESPECTIVELY, THAN ACRIFLAVINE HYDROCHLORIDE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

T4光灭活在与乙啶红孵化后被观察到。这种灭活遵循单次击中动力学，与辐射时间有关。

T4 PHOTOINACTIVATION WAS OBSERVED AFTER INCUBATION WITH ACRIDINE RED. THE INACTIVATION FOLLOWED SINGLE HIT KINETICS AS A FUNCTION OF THE IRRADIATION TIME.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

对兔眼有中等伤害。

MODERATELY INJURIOUS TO RABBIT EYES.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在测试的20种染料中，之前声称可以通过胰腺消除的，只有6种出现在狗的胰液中。胰液中染料颜色的强度按以下顺序降低：碱性品红、吖啶红、新品红、罗丹明B、酚红和罗丹明6G。氯含量与淀粉酶或染料含量有关，但与分泌量成反比。

OF THE 20 DYES TESTED, ALL PREVIOUSLY CLAIMED TO BE ELIMINATED THROUGH THE PANCREAS, ONLY 6 APPEARED IN THE PANCREATIC JUICE OF DOGS. THE INTENSITY OF DYE COLOR IN PANCREATIC JUICE DECREASED IN THE ORDER: BASIC FUCHSINE, ACRIDINE RED, NEW FUCHSINE, RHODAMINE B, PHENOL RED, & RHODAMINE 6G. THE CHLORINE CONTENT WAS RELATED TO AMYLASE OR DYE CONTENT, BUT WAS INVERSELY RELATED TO SECRETED VOLUME.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在测试的20种染料中，所有先前声称可以通过胰腺消除的，只有在狗的胰液中出现了6种。胰液中染料颜色的强度按以下顺序降低：碱性品红、吖啶红、新品红、罗丹明B、酚红和罗丹明6G。氯含量与淀粉酶或染料含量有关，但与分泌量成反比。

OF THE 20 DYES TESTED, ALL PREVIOUSLY CLAIMED TO BE ELIMINATED THROUGH THE PANCREAS, ONLY 6 APPEARED IN THE PANCREATIC JUICE OF DOGS. THE INTENSITY OF DYE COLOR IN PANCREATIC JUICE DECREASED IN THE ORDER: BASIC FUCHSINE, ACRIDINE RED, NEW FUCHSINE, RHODAMINE B, PHENOL RED, & RHODAMINE 6G. THE CHLORINE CONTENT WAS RELATED TO AMYLASE OR DYE CONTENT, BUT WAS INVERSELY RELATED TO SECRETED VOLUME.

来源:Hazardous Substances Data Bank (HSDB)

表征谱图