Ponceau 4R (85%)

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Ponceau 4R (85%)
• 英文别名: trisodium;7-hydroxy-8-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonate
• 化学式: C20H11N2Na3O10S3
• 分子量: 604.5
• InChiKey: SWGJCIMEBVHMTA-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -6.16
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  242
• 氢给体数：
  1
• 氢受体数：
  12

ADMET

毒理性

• 相互作用

RED NUMBER 102 (NEW COCCINE, NC) 加入到基础纯化、低纤维饮食（25%酪蛋白-蔗糖）中的5%水平时，会导致严重的生长迟缓。同时添加来自牛蒡根（大根菜，ARCTIUM LAPPA L）的可食用膳食纤维（GDF）完全防止了新可可碱的毒性。

RED NUMBER 102 (NEW COCCINE, NC) CAUSED SEVERE GROWTH RETARDATION WHEN ADDED TO A BASAL PURIFIED, LOW-FIBER DIET (25% CASEIN-SUCROSE) AT 5% LEVEL. THE CONCURRENT ADDITION OF DIETARY FIBER (GDF) FROM GOBO, THE ROOTS OF EDIBLE BURDOCK (ARCTIUM LAPPA L), COMPLETELY PROTECTED AGAINST THE TOXICITY OF NEW COCCINE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

一些患有哮喘、鼻炎或荨麻疹的患者在摄入含有偶氮染料的食物或饮料后，症状会加剧。这些患者可能会被误认为是患有特定食物过敏。药物及其涂层可能含有偶氮染料，因此遵循无添加剂饮食的患者应避免使用。/偶氮染料/

SOME PATIENTS WHO SUFFER FROM ASTHMA, RHINITIS OR URTICARIA UNDERGO EXACERBATION OF SYMPTOMS FOLLOWING INGESTION OF FOODS OR BEVERAGES CONTAINING AZO DYES. THESE PATIENTS MAY BE MISTAKENLY THOUGHT TO BE SUFFERING FROM SPECIFIC FOOD ALLERGIES. DRUGS & THEIR COATINGS MAY CONTAIN AZO DYES & THESE SHOULD BE AVOIDED BY PATIENTS ON AN ADDITIVE-FREE DIET. /AZO DYES/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

食品红编号102的慢性毒性在SLC-Wistar大鼠的雌雄两性中进行了研究，饮食中补充了2%的添加剂。研究了20只雄性和20只雌性大鼠，为期12个月。食用红编号3的大鼠生长速度低于食用红编号102的大鼠，而食用红编号3和编号102的大鼠生长速度与食用红编号102的大鼠相当。一只食用红编号102的雌性大鼠盲肠中发展出了一例平滑肌肉瘤。在对照组中，20只雄性和20只雌性大鼠中有1只雄性和1只雌性在皮下组织中发展出了纤维瘤。食用红编号102的大鼠中没有明显的毒性迹象。

CHRONIC TOXICITY OF FOOD RED NUMBER 102 WAS INVESTIGATED IN SLC-WISTAR RATS OF BOTH SEXES, SUPPLEMENTING DIET WITH 2% ADDITIVE. 20 MALES & 20 FEMALES /WERE/ STUDIED FOR 12 MONTHS. RATS FED RED NUMBER 3 GREW LESS THAN THESE FED RED NUMBER 102, WHILE THOSE FED RED NUMBER 3 & NUMBER 102 GREW COMPARABLE TO THOSE FED RED NUMBER 102. ONE FEMALE FED RED NO 102 DEVELOPED A LEIOMYOSARCOMA IN THE CECUM. IN CONTROL, ONE OUT OF 20 MALES & ONE OUT OF 20 FEMALES DEVELOPED FIBROMA IN THE SUBCUTANEOUS TISSUE. NO TOXICITY WAS EVIDENT IN RATS FED RED NUMBER 102.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在每天饲喂100-300毫克/千克的Ponceau 4R的猪和对照组动物之间，生长、尿液和血清的组成、器官重量或组织病理学方面没有观察到差异。观察到红细胞计数略有减少。

NO DIFFERENCES IN GROWTH, COMPOSITION OF URINE & SERUM, ORGAN WEIGHTS OR HISTOPATHOLOGY WERE OBSERVED BETWEEN PIGS FED PONCEAU 4R 100-300 MG/KG/DAY, 90 DAYS AND CONTROL ANIMALS. A SLIGHT REDUCTION IN THE ERYTHROCYTE COUNT WAS OBSERVED.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

当以0.67微摩尔浓度添加到大鼠肾脏匀浆中时，新可可碱降低了呼吸速率。

WHEN ADDED TO RAT KIDNEY HOMOGENATES AT O.67 UMOLE, NEW COCCINE DECREASED THE RESPIRATION RATE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

新可可碱50-100微摩尔静脉注射给肾蒂结扎的大鼠，胆汁排泄率达到了明显的最大值，这个最大值会被酚酞葡萄糖苷酸或丙磺舒（两者均为50微摩尔）所抑制。胆汁排泄可能涉及一个主动运输过程。

THE BILIARY EXCRETION RATES OF NEW COCCINE 50-100 UMOLE ADMINISTERED IV TO RATS WITH LIGATED RENAL PEDICLES, REACHED APPARENT MAXIMA WHICH WERE DEPRESSED BY PHENOLPHTHALEIN GLUCURONIDE OR PROBENECID (BOTH 50 UMOLE). BILIARY EXCRETION MAY INVOLVE AN ACTIVE TRANSPORT PROCESS.

来源:Hazardous Substances Data Bank (HSDB)