Ferric Sulfate | 10028-22-5

• 物质功能分类: 无机化工 - 无机盐 - 金属硫化物及硫酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属氧阴离子化合物
• 英文名称: Ferric Sulfate
• 英文别名: iron(3+);trisulfate
• CAS: 10028-22-5
• 化学式: Fe2O12S3
• 分子量: 399.9
• InChiKey: RUTXIHLAWFEWGM-UHFFFAOYSA-H

物化性质

• 熔点：
  480°C
• 沸点：
  101-118 °C
• 密度：
  3.097
• 溶解度：
  微溶于乙醇；不溶于丙酮
• 暴露限值：
  ACGIH: TWA 1 mg/m3NIOSH: TWA 1 mg/m3
• LogP：
  -1.031 (est)
• 物理描述：
  Ferric sulfate appears as a yellow crystalline solid or a grayish-white powder. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used for water purification, and as a soil conditioner.
• 颜色/状态：
  Grayish-white powder, or rhombic or rhombohedral crystals
• 稳定性/保质期：

  1. 浅黄色粉末，在潮湿空气中易潮解，变成棕色溶液。480℃时分解生成氧化铁和三氧化硫。常见的水合物为九水合物Fe2(SO4)3·9H2O，分子量562.01，呈黄色，密度为2.1g/cm³。在酸性溶液中有较强氧化性，可溶解铁、铜等。

  2. 工作人员应做好防护措施，若不慎触及皮肤和眼睛，应立即用流动清水冲洗。工作环境需保持良好通风。存于密闭容器内，并置于凉爽、通风处。该物质具有很强的吸湿性，能溶于水，但溶解缓慢且会发生水解。

• 分解：
  When heated to decomposition it emits toxic fumes /of iron and sulfur oxides./
• 腐蚀性：
  Corrosive to copper, copper alloys, mild steel, and galvanized steel.
• 折光率：
  Index of refraction: 1.814

计算性质

• 辛醇/水分配系数(LogP)：
  -4.02
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  266
• 氢给体数：
  0
• 氢受体数：
  12

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

短暂的暴露（1小时）于含有51Cr放射性标记的乳腺癌细胞（BT-20），而不是结肠癌细胞（Caco-2）的血红素（10微摩尔）或硫酸亚铁（10微摩尔），可以显著增强由0.5毫摩尔过氧化氢（H2O2）介导的细胞毒性。与Caco-2的抵抗性相关，这些细胞被发现富含内源性铁螯合剂，铁蛋白。如果通过血红素、硫酸亚铁或外源性脾无铁铁蛋白本身（24小时）与两种细胞类型进行1小时孵化进一步增加细胞铁蛋白，就会明显表现出对 介导的细胞毒性的抵抗。在几种情况下，肿瘤细胞对氧化剂介导的裂解的敏感性与其铁蛋白含量成反比。用血红素或硫酸亚铁预处理BT-20和Caco-2细胞迅速增加H-铁蛋白mRNA，但仅略微增加L-铁蛋白mRNA；尽管如此，铁暴露细胞的总体铁蛋白含量大幅增加。在研究博来霉素诱导的DNA链断裂和细胞损伤的实验中，得到了与 介导的细胞毒性类似的数据，即血红素或硫酸亚铁短暂处理BT-20细胞显著增加了它们对博来霉素（100微克/毫升）的敏感性，而处理后仅用培养基进行24小时孵化则显著抵抗博来霉素的毒性。

...A brief exposure (1 hr) of 51Cr-radiolabeled breast cancer cells (BT-20) but not colon cancer cells (Caco-2) to hemin (10 uM) or FeSO4 (10 uM) significantly enhances cytotoxicity mediated by 0.5 mM hydrogen peroxide (H2O2). Associated with Caco-2 resistance, these cells were found to be enriched in the endogenous iron chelator, ferritin. If cellular ferritin is even further increased through 1 hr incubation (24 hr prior to H2O2 exposure) of both cell types with hemin, FeSO4, or exogenous spleen apoferritin itself (24 hr), marked resistance to H2O2-mediated cytotoxicity is manifest. Under several conditions, the sensitivity of tumor cells to oxidant-mediated lysis is inversely proportional to their ferritin content. Pretreatment of BT-20 and Caco-2 cells with hemin or FeSO4 rapidly increases H-ferritin mRNA but only slightly increases L-ferritin mRNA; nevertheless, large increases in overall ferritin content of iron-exposed cells result. Data analogous to those with H2O2-mediated cytotoxicity were obtained in studies of bleomycin-engendered DNA strand breakage and cell damage, i.e., brief treatment of BT-20 cells with both hemin or FeSO4 significantly increases their sensitivity to bleomycin (100 ug/mL), whereas treatment followed by 24 hr incubation with media alone significantly protects against bleomycin toxicity.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并视需要进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于误食，如果患者能够吞咽，有强烈的呕吐反射，且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。/铁及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口咽或鼻咽气管插管以控制气道。监测心率和必要时治疗心律失常。开始静脉输液，使用乳酸钠林格氏液/生理盐水： "保持开放"，最低流速。注意液体过载的迹象。对于伴有低血容量症状的低血压，谨慎给予液体。注意液体过载的迹象。使用丙美卡因氢氯化物协助眼部冲洗。/铁及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

铁缺乏饮食(每千克饮食含铁8毫克)14天。然后将贫血大鼠分为三组，每组11只。第1组(对照组)喂食含铁充足的饮食(每千克饮食含铁45毫克)，并通过瘘管灌注NaCl溶液(150 mM)。第2组和第3组喂食铁缺乏饮食，并通过瘘管灌注硫酸亚铁[Fe(II)]悬浮液或硫酸铁[Fe(III)]溶液(以Fe计800 ppm，pH 6.8)，以提供与对照组前一日摄入的铁量相同的铁。NaCl、Fe(II)和Fe(III)通过瘘管以两次(1000小时和1800小时)的方式连续14天灌注。灌注的NaCl体积大约等于Fe(II)悬浮液和Fe(III)溶液的体积。血红蛋白再生效率、血细胞比容、血浆铁浓度、转铁蛋白饱和度、总铁结合能力、器官(肝脏、脾脏和肾脏)中铁含量、体重增加和食物摄入量在各组之间几乎相同。

The bioavailability of ferrous and ferric iron following cecal infusion was compared by assessing the hemoglobin regeneration method in ileally fistulated anemic rats. Rats were fed an iron-deficient diet (8 mg Fe/kg diet) for 14 days after recovery from surgery. The anemic rats were then divided into three groups of 11 rats. Group 1 (control) was fed an iron-adequate diet (45 mg Fe/kg diet) and infused with NaCl solution (150 mM). Group 2 and 3 were fed an iron-deficient diet and infused with ferrous sulfate [Fe(II)] suspension or ferric sulfate [Fe(III)] solution (800 ppm as Fe, pH 6.8) to provide the same amount of iron as that consumed one day before by the control group. NaCl, Fe(II) and Fe(III) were infused through the fistula as two times (1000 hr and 1800 hr) for 14 days. The volume of NaCl infused was about equal to the volume of Fe(II) suspension and Fe(III) solution infused. Hemoglobin regeneration efficiency, hematocrit, plasma iron concentration, transferrin saturation, total iron-binding capacity, iron contents in organs (liver, spleen and kidney), body weight gain and food intake were almost the same among groups.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S26
• 危险类别码：
  R36/37,R22
• WGK Germany：
  3
• 危险品运输编号：
  UN 9121
• RTECS号：
  NO8520000

SDS

Name:	Ferric Sulfate Monohydrate Material Safety Data Sheet
Synonym:	Diiron Trisulfate; Ferric Sulfate; Iron Persulfate; Iron Sesquisulfate; Iron Sulfate (2:3); Iron (3+) Sulfate; Sulfuric Acid, Iro
CAS:	10028-22-5

Section 1 - Chemical Product MSDS Name:Ferric Sulfate Monohydrate Material Safety Data Sheet
Synonym:Diiron Trisulfate; Ferric Sulfate; Iron Persulfate; Iron Sesquisulfate; Iron Sulfate (2:3); Iron (3+) Sulfate; Sulfuric Acid, Iro

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10028-22-5	Ferric sulfate, monohydrate	100	233-072-9

Hazard Symbols: XN
Risk Phrases: 22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause liver and kidney damage.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Discard contaminated shoes.
Storage:
Store in a cool, dry place. Keep containers tightly closed.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 10028-22-5: Belgium - TWA: (listed as iron salts (soluble)): 1 mg/m3 VLE (as Malaysia: (listed as iron salts (soluble)): 1 mg/m3 TWA (as Fe) Netherlands: (listed as iron salts (soluble)): 1 mg/m3 MAC (as Fe Spain: (listed as iron salts (soluble)): 1 mg/m3 VLA-ED (as Fe) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow-gray
Odor: odorless
pH: Not available.
Vapor Pressure: Negligible.
Viscosity: Not available.
Boiling Point: Not applicable.
Freezing/Melting Point: Decomposes.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 480 deg C
Solubility in water: Soluble in water.
Specific Gravity/Density: 3.097
Molecular Formula: Fe2(SO4)3.H2O
Molecular Weight: 399.8668

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Corrosive to metals.
Hazardous Decomposition Products:
Sulfur oxides (SOx), including sulfur oxide and sulfur dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10028-22-5: NO8505000 LD50/LC50:
Not available.
Carcinogenicity:
Ferric sulfate, monohydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 10028-22-5: 1000 lb final RQ; 454 kg final RQ

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 10028-22-5: 1
Canada
CAS# 10028-22-5 is listed on Canada's DSL List.
CAS# 10028-22-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10028-22-5 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

聚合硫酸铁是一种广泛应用于水处理、冶金等多个领域的化学物质。其主要特点和应用如下：

特点

• 化学性质：固体为淡黄色颗粒，液体呈红褐色粘稠状。
• 溶解性：在20℃的水中能溶解440g/100ml。
• 毒性分级：属中毒类物质，急性腹腔注射小鼠LD50值为168毫克/公斤。
• 可燃性：不可燃烧，在火灾条件下会生成有毒的含铁硫氧化物烟雾。

应用

1. 水处理：作为无机高分子絮凝剂用于城镇生活饮用水、工业给水方面，能有效去除水中悬浮物和胶体颗粒。
2. 分析试剂与催化：用于银的分析、糖定时测定等科学研究领域；也可作为铁催化剂及媒染剂使用。

生产方法

• 钛白粉法：通过硝酸氧化硫酸亚铁制得。
• 氧气氧化法：在密闭容器中通入纯氧，在特定温度下反应生成聚合硫酸铁。
• 氯酸钾氧化法：利用氯酸钾与硫酸亚铁反应生产。

工艺改进

近年来，为提高生产效率和降低能耗，出现了基于反应塔的生产工艺。这种方法通过增加混合液在反应塔中的流动表面积来加快反应速度，并可加压操作以进一步提高转化率。

安全储存及运输

• 应存放在低温、通风良好且干燥的地方。
• 需密封保存以防受潮影响性能。
• 运输过程中应避免接触明火或高温环境，使用二氧化碳、干粉灭火器等作为火灾应对手段。

总之，聚合硫酸铁因其良好的絮凝效果及广泛的应用领域，在水处理行业中占据重要地位。同时需要注意其毒性管理与安全储存运输问题。

反应信息

• 作为反应物：
  描述：

  Ferric Sulfate 生成 Oxido(oxo)iron;oxoiron;oxoiron(1+)
  参考文献：
  名称：

  ASAMI, KENJI;OHTSUKA, YASUO, INT. CONF. COAL SCI., TOKYO, OCT. 23-27, 1989, SAN JOSE (CALIF.),(1989) C+

  摘要：

  DOI：
• 作为产物：
  描述：

  铁(2+)硫酸酯 生成 Ferric Sulfate
  参考文献：
  名称：

  SONTA, HIROMI;SHIRATORI, TOSHIKAZU;STREHL, SCHUBEL-HOPF

  摘要：

  DOI：
• 作为试剂：
  描述：

  (+/-)-二氢硫辛酸 、 sodium hydroxide 在 甲基叔丁基醚 、 乙醚 、 水 、 Ferric Sulfate 、 铁粉 、 盐酸 、 crude product 、 ethyl acetate n-hexane 作用下， 以 水 为溶剂， 反应 3.5h， 以were obtained 5.9 grams (75% of theory) of 1,2-dithiolane-3-pentanoic acid as yellow crystals的产率得到(±)-α-硫辛酸
  参考文献：
  名称：

  Process for the production of 1,2-dithiolan-3-pentanoic acid (thioctic

  摘要：

  公式为 ##STR1## 的1,2-二硫杂环戊酸（D，L-硫辛酸）通过以下步骤制备：（a）将公式为 ##STR2## 的2-（3-烷基硫代丙酰基）-环戊酮-1在水性碱溶液中反应，在约20℃至90℃的温度下形成相应的羧酸，其化学式为VI；（b）将化合物VI与烷基硫醇在-20℃至0℃的温度下反应，形成相应的硫代醛，其化学式为VII；（c）将化合物VII与液氨中的钠在-60℃至-10℃的温度下反应，形成化学式为VIII的6,8-二硫辛酸；（d）将化学式为VIII的6,8-二硫辛酸在碱性溶液中与铁（III）盐和氧反应，形成化学式为IX的1,2-二硫杂环戊酸。或者，可以使用化学式为XII的酸与液氨中的钠在-60℃至-10℃的温度下反应，形成相应的化学式为VIII的6,8-二硫辛酸，其中R1和R2为氢，C1-C4烷基，苯基或苄基，但R1和R2不能同时为苄基。化学式VI，VII和XII的化合物是新的。

  公开号：

  US04966732A1

文献信息

• LALVANI, S. B.;RAMASWAMI, K., TRANS. ASME. J. ENERGY RESOUR. TECHNOL., 110,(1988) N, C. 269-275
  作者：LALVANI, S. B.、RAMASWAMI, K.

  DOI：——

  日期：——
• BELOV, V. N.;VASHKEVICH, N. G., ISSLED. V OBL. TEXNOL. FOSFORSODERZH. PRODUKTOV I SULFIT. SOLEJ, L.,(1988+
  作者：BELOV, V. N.、VASHKEVICH, N. G.

  DOI：——

  日期：——
• PESIC, BATRIC;SEAL, THOM, PRECIOUS METALS89, WARRENDALE (PA),(1988(1989)) C. 261-285
  作者：PESIC, BATRIC、SEAL, THOM

  DOI：——

  日期：——
• HOLZINGER, HANS-WERNER;TEUTSCH, MARKUS;RUDOLPH, RICHARD;DUNKEN, HELGA
  作者：HOLZINGER, HANS-WERNER、TEUTSCH, MARKUS、RUDOLPH, RICHARD、DUNKEN, HELGA

  DOI：——

  日期：——
• POLENDO-LOREDO, JOSE
  作者：POLENDO-LOREDO, JOSE

  DOI：——

  日期：——