N-ethyl-6-hydroxy-2,5,7,8-tetramethyl-N-(pyridin-2-ylmethyl)chromane-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-ethyl-6-hydroxy-2,5,7,8-tetramethyl-N-(pyridin-2-ylmethyl)chromane-2-carboxamide
• 英文别名: N-ethyl-6-hydroxy-2,5,7,8-tetramethyl-N-(pyridin-2-ylmethyl)-3,4-dihydrochromene-2-carboxamide
• 化学式: C₂₂H₂₈N₂O₃
• 分子量: 368.5
• InChiKey: XLKQBQONODQJTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOUNDS AND COMPOSITIONS FOR INHIBITING RETINAL PIGMENT EPITHELIUM DEGENERATION AND METHODS USING THE SAME
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20200316032A1

  公开（公告）日：2020-10-08

  There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.