2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4-dimethyl-1-((1-(1-methylcyclopropanecarbonyl)azetidin-3-yl)methyl)-1H-imidazol-5(4H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4-dimethyl-1-((1-(1-methylcyclopropanecarbonyl)azetidin-3-yl)methyl)-1H-imidazol-5(4H)-one
• 英文别名: 2-[2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl]-5,5-dimethyl-3-[[1-(1-methylcyclopropanecarbonyl)azetidin-3-yl]methyl]imidazol-4-one
• 化学式: C₃₀H₂₉F₂N₃O₂
• 分子量: 501.576
• InChiKey: UDVYJDDXFMTKLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Janssen Pharmaceutica, NV

  公开号：US20150166529A1

  公开（公告）日：2015-06-18

  The present invention is directed to imidazolin-5-one derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n, and are defined herein.

  本发明涉及咪唑啉-5-酮衍生物，含有它们的药物组合物，以及它们作为FASN抑制剂的用途，例如用于治疗癌症、肥胖相关疾病和肝脏相关疾病。此类化合物由以下式子表示： 其中R1、R2、R3、R4、R5、m、n和在此处定义。
• Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
  申请人：Janssen Pharmaceutica NV

  公开号：US10413545B2

  公开（公告）日：2019-09-17

  The present invention is directed to imidazolin-5-one derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein R1, R2, R3, R4, R5, m, n, and are defined herein.

  本发明涉及咪唑啉-5-酮衍生物、含有它们的药物组合物，以及它们作为 FASN 抑制剂在治疗癌症、肥胖相关疾病和肝脏相关疾病等方面的用途。这类化合物由如下式（I）表示： 其中 R1、R2、R3、R4、R5、m、n 和 在此定义。
• IMIDAZOLIN-5-ONE DERIVATIVES USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Janssen Pharmaceutica NV

  公开号：EP3083600B1

  公开（公告）日：2018-09-26
• US9718813B2
  申请人：——

  公开号：US9718813B2

  公开（公告）日：2017-08-01
• [EN] IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉ D'IMIDAZOLINE-5-ONE UTILE EN TANT QU'INHIBITEUR DE FAS POUR LE TRAITEMENT DU CANCER
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015095011A1

  公开（公告）日：2015-06-25

  The present invention is directed to imidazolin-5-one derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the treatment of cancer, obesity related disorders, and liver related disorders. Such compounds are represented by formula (I) wherein R1,R2,R3, R4, R, m, n are defined herein.