(2Z)-2-[(E)-3-[3-(5-carboxypentyl)-1,1-dimethyl-6,8-disulfobenzo[e]indol-3-ium-2-yl]prop-2-enylidene]-3-ethyl-1,1-dimethyl-8-(trioxidanylsulfanyl)benzo[e]indole-6-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2Z)-2-[(E)-3-[3-(5-carboxypentyl)-1,1-dimethyl-6,8-disulfobenzo[e]indol-3-ium-2-yl]prop-2-enylidene]-3-ethyl-1,1-dimethyl-8-(trioxidanylsulfanyl)benzo[e]indole-6-sulfonate
• 化学式: C39H42N2O14S4
• 分子量: 891.0
• InChiKey: KJAPCNUKFFDKMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  59
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  299
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• Methods for nucleic acid sequencing
  申请人：Quantum-Si Incorporated

  公开号：US10174363B2

  公开（公告）日：2019-01-08

  Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.

  本文提供了基于发光寿命和/或发光强度的分子测序方法。在某些方面，核酸测序方法包括确定在核酸测序反应期间加入的一系列发光标记核苷酸的发光寿命和发光强度。
• METHOD OF DETERMINING THE SEQUENCE OF A NUCLEIC ACID USING TIME RESOLVED LUMINESCENCE
  申请人：Quantum-Si Incorporated

  公开号：EP3298389B1

  公开（公告）日：2021-09-29
• LABELED NUCLEOTIDE COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
  申请人：Quantum-si Incorporated

  公开号：EP3458465A1

  公开（公告）日：2019-03-27
• METHODS FOR NUCLEIC ACID SEQUENCING
  申请人：Quantum-Si Incorporated

  公开号：US20170107562A1

  公开（公告）日：2017-04-20

  Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.
• HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING
  申请人：Quantum-Si Incorporated

  公开号：US20190024168A1

  公开（公告）日：2019-01-24

  Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.