1-(p-Aminophenyl)-3-oxo-1,2,3,4-tetrahydro-isochinolin | 54087-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-(p-Aminophenyl)-3-oxo-1,2,3,4-tetrahydro-isochinolin
• 英文别名: 1-(4-amino-phenyl)-1,4-dihydro-2H-isoquinolin-3-one；1-(4-Aminophenyl)-1,4-dihydroisoquinolin-3(2H)-one；1-(4-aminophenyl)-2,4-dihydro-1H-isoquinolin-3-one
• CAS: 54087-54-6
• 化学式: C₁₅H₁₄N₂O
• 分子量: 238.289
• InChiKey: XUZIJAZCGHGONC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(p-Aminophenyl)-3-oxo-1,2,3,4-tetrahydro-isochinolin 以91%的产率得到
  参考文献：
  名称：

  DEAK G.; DODA M.; GYOERGY L.; HAZAI L.; STERK L., J. MED. CHEM. , 1977, 20, NO 11, 1384-1388

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(4'-Nitrophenyl)-1,4-dihydro-3(2H)-isoquinolinone 生成 1-(p-Aminophenyl)-3-oxo-1,2,3,4-tetrahydro-isochinolin
  参考文献：
  名称：

  DEAK G.; DODA M.; GYOERGY L.; HAZAI L.; STERK L., J. MED. CHEM. , 1977, 20, NO 11, 1384-1388

  摘要：

  DOI：

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020052359A1

  公开（公告）日：2002-05-02

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制β-淀粉样肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的用途。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Thorsett D. Eugene

  公开号：US20070203108A1

  公开（公告）日：2007-08-30

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制β-淀粉样肽的释放和/或合成的化合物，因此在治疗阿尔茨海默病方面具有用途。同时，本发明还涉及包含抑制β-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这些药物组合物预防和治疗阿尔茨海默病的方法。
• HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING $g(b)-AMYLOID PEPTIDE
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP0968198A1

  公开（公告）日：2000-01-05
• COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1089980A1

  公开（公告）日：2001-04-11
• US3946018A
  申请人：——

  公开号：US3946018A

  公开（公告）日：1976-03-23