Bupivacaine 3-hydroxy-2-naphthoate | 66558-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Bupivacaine 3-hydroxy-2-naphthoate
• 英文别名: 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;3-hydroxynaphthalene-2-carboxylic acid
• CAS: 66558-79-0
• 化学式: C29H36N2O4
• 分子量: 476.6
• InChiKey: GPBFSNHGCGQMGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.14
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• INSOLUBLE COMPLEX OR SOLVATE THEREOF, PHARMACEUTICAL COMPOSTION AND USE THEREOF
  申请人：HEFEI COSOURCE PHARMACEUTICALS INC

  公开号：US20210087144A1

  公开（公告）日：2021-03-25

  The present invention provides a complex of formula (I) or a solvate thereof (wherein n is 1 to 4), a pharmaceutical composition, and use of the pharmaceutical composition in the prevention or treatment of surgical pain, intraoperative pain and postsurgical pain. The technical solution according to the present invention provides a medicament which can be produced by a simple production process and can stably release a local anesthetic in body for a long period. The medicament can be released for at least three days or more, which can prolong the analgesic effect on the postsurgical pain, can be used conveniently by the physician and the patient, and has a good treatment compliance.

  本发明提供了一种具有式（I）的复合物或其溶剂结晶物（其中n为1至4），一种药物组合物，以及药物组合物在预防或治疗手术疼痛、术中疼痛和术后疼痛中的用途。根据本发明的技术方案提供了一种药物，可以通过简单的生产过程生产，并且可以在体内稳定释放局部麻醉剂长时间。该药物可以释放至少三天或更长时间，可以延长对术后疼痛的镇痛效果，可以方便地由医生和患者使用，并具有良好的治疗依从性。
• POORLY SOLUBLE COMPLEX OR SOLVATE THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
  申请人：FRUITHY HOLDINGS LIMITED

  公开号：EP3486233A1

  公开（公告）日：2019-05-22

  The present invention provides a complex of formula (I) or a solvate thereof (wherein n is 1 to 4), a pharmaceutical composition, and use of the pharmaceutical composition in the prevention or treatment of surgical pain, intraoperative pain and postsurgical pain. The technical solution according to the present invention provides a medicament which can be produced by a simple production process and can stably release a local anesthetic in body for a long period. The medicament can be released for at least three days or more, which can prolong the analgesic effect on the postsurgical pain, can be used conveniently by the physician and the patient, and has a good treatment compliance.

  本发明提供了一种式（I）的复合物或其溶液（其中n为1至4）、一种药物组合物，以及该药物组合物在预防或治疗手术疼痛、术中疼痛和术后疼痛中的用途。根据本发明的技术方案，提供了一种可通过简单的生产工艺生产并可在体内长期稳定释放局麻药的药物。该药剂至少可释放三天以上，可延长对术后疼痛的镇痛效果，方便医生和患者使用，治疗依从性好。
• Insoluble complex or solvate thereof, pharmaceutical composition and use thereof
  申请人：Fruithy Holdings Limited

  公开号：US11084790B2

  公开（公告）日：2021-08-10

  The present invention provides a complex of formula (I) or a solvate thereof (wherein n is 1 to 4), a pharmaceutical composition, and use of the pharmaceutical composition in the prevention or treatment of surgical pain, intraoperative pain and postsurgical pain. The technical solution according to the present invention provides a medicament which can be produced by a simple production process and can stably release a local anesthetic in body for a long period. The medicament can be released for at least three days or more, which can prolong the analgesic effect on the postsurgical pain, can be used conveniently by the physician and the patient, and has a good treatment compliance.

  本发明提供了一种式（I）的复合物或其溶液（其中n为1至4）、一种药物组合物，以及该药物组合物在预防或治疗手术疼痛、术中疼痛和术后疼痛中的用途。根据本发明的技术方案，提供了一种可通过简单的生产工艺生产并可在体内长期稳定释放局麻药的药物。该药剂至少可释放三天以上，可延长对术后疼痛的镇痛效果，方便医生和患者使用，治疗依从性好。