Disodium;6-oxido-4-sulfonaphthalene-2-sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Disodium;6-oxido-4-sulfonaphthalene-2-sulfonate
• 英文别名: disodium;6-oxido-4-sulfonaphthalene-2-sulfonate
• 化学式: C10H6Na2O7S2
• 分子量: 348.3
• InChiKey: IEXIPYCHASVPFD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.64
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  151
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Allantoin-containing preparations for administration as gels and aerosols
  申请人：Alwyn Company, Inc.

  公开号：US20030147968A1

  公开（公告）日：2003-08-07

  Allantoin-containing preparations are prepared in a form suitable for administration as gels and aerosols. In one embodiment of the aerosol formulation, an allantoin-containing composition comprises: (1) water; (2) allantoin in a therapeutically effective quantity; (3) an anionic ethoxylated surfactant; (4) lanolin oil; and (5) cod liver oil. The composition has a viscosity and surface tension in a range that allows the composition to be administered to the skin of a user as an aerosol by a mechanical spray pump. In another aspect of this invention, the allantoin-containing preparations are prepared in a form suitable for administration as gels. The compositions can be substantially anhydrous or can contain water. In one embodiment of the gel formation, an allantoin-containing composition comprises: (1) allantoin in a therapeutically effective quantity; (2) a complex comprising mineral oil and at least one hydrogenated alkylene copolymer; (3) lanolin oil; and (4) cod liver oil. The compositions can comprise other ingredients. Compositions according to the present invention are suitable for the treatment of a number of skin conditions or diseases characterized by ulceration, inflammation, or blistering of the skin, such as epidermolysis bullosa.

  含有尿囊素的制剂以适合作为凝胶和气雾剂的形式制备。在气雾剂配方的一个实施例中，含有尿囊素的组合物包括：（1）水；（2）疗效有效量的尿囊素；（3）阴离子乙氧基化表面活性剂；（4）羊毛脂油；和（5）鱼肝油。该组合物具有粘度和表面张力范围，使得通过机械喷雾泵将组合物作为气雾施用到用户皮肤上。在这项发明的另一个方面，含有尿囊素的制剂以适合作为凝胶的形式制备。这些组合物可以是几乎无水的，也可以含水。在凝胶形成的一个实施例中，含有尿囊素的组合物包括：（1）疗效有效量的尿囊素；（2）包括矿物油和至少一种氢化烷烯共聚物的复合物；（3）羊毛脂油；和（4）鱼肝油。这些组合物可以包含其他成分。根据本发明的组合物适用于治疗一系列皮肤状况或疾病，其特征是皮肤溃疡、炎症或水疱，如表皮溶解性水疱症。
• ARYL SULFONIC ACID COMPOUND AND USE OF SAME
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3101002A1

  公开（公告）日：2016-12-07

  An aryl sulfonic acid compound represented by formula (1).         Ar1-O-Ar2     (1) [In the formula, Ar1 represents a group represented by formula (2), and Ar2 represents a group represented by formula (3). (in the formula, q represents an integer of 1-4.)]

  式 (1) 所代表的芳基磺酸化合物。 Ar1-O-Ar2 (1) [式中，Ar1 代表由式（2）表示的基团，Ar2 代表由式（3）表示的基团。 (式中，q 代表 1-4 的整数）]。
• Methods for treatment of inflammatory diseases
  申请人：——

  公开号：US20020055531A1

  公开（公告）日：2002-05-09

  An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is an oil-in-water emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include an acidic wax such as beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone. In still another alternative, the emulsifier system can include cetyl alcohol and stearic acid. In yet another alternative, the emulsifier system can include sodium stearoyl lactylate and sodium isostearoyl lactylate. In another alternative, the emulsifier system can include at least one polyethyleneglycol ether of cetearyl alcohol. In still another alternative, the emulsifier system can include a polyethylene glycol ester of stearic acid and glyceryl stearate. The composition can include other ingredients. The pH of the composition used in a method according to the present invention is from about 3.0 to about 6.0; preferably, a narrower pH range is used, varying with each embodiment of the composition. Among the diseases that can be treated is epidermolysis bullosa.

  一种治疗皮肤病的改进方法包括向皮肤病患者的皮肤施用治疗有效量的含尿囊素的组合物。这种含尿囊素的组合物是一种水包油型乳剂，它包括尿囊素和一种乳化剂体系，该体系包括至少一种乳化剂，这种乳化剂可以是阴离子乳化剂，也可以是非离子乳化剂。如果乳化剂是阴离子乳化剂，乳化剂体系可包括酸性蜡，如蜂蜡。所用的非离子乳化剂可包括至少一种非离子乳化剂，它是一种乙氧基化醚或乙氧基化酯，其碳链长度范围为 8 至 22 个碳原子。或者，乳化剂体系可以包括酸性阴离子聚合物，如羧基聚亚甲基和阴离子乳化剂。另一种选择是，乳化剂体系可包括酸性阴离子聚合物和非离子乳化剂，或仅包括酸性阴离子聚合物。还有一种选择是，乳化剂体系可以包括十六烷基醇和硬脂酸。在另一种选择中，乳化剂体系可包括硬脂酰乳酰酸钠和异硬脂酰乳酰酸钠。在另一种选择中，乳化剂体系可以包括至少一种鲸蜡硬脂醇聚乙二醇醚。还有一种选择是，乳化剂体系可以包括硬脂酸聚乙二醇酯和硬脂酸甘油酯。组合物还可以包括其他成分。根据本发明的方法使用的组合物的 pH 值为约 3.0 至约 6.0；优选使用较窄的 pH 值范围，随组合物的每个实施方案而变化。可治疗的疾病包括表皮松解症。
• Allantoin-containing skin cream
  申请人：Alwyn Company, Inc.

  公开号：US20020054895A1

  公开（公告）日：2002-05-09

  An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The composition is in the form of an oil-in-water emulsion. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.

  含尿囊素的护肤霜组合物可包含尿囊素和至少一种亲水性和可溶于水的阴离子或非离子乳化剂。组合物为水包油型乳液。组合物的 pH 值在约 3.0 到约 6.0 之间；优选地，组合物的 pH 值在约 5.0 到约 6.0 之间。组合物还可以包含酸性阴离子聚合物。优选的酸性阴离子聚合物是羧基聚亚甲基聚合物。组合物还可以包含碳水化合物聚合物，如半乳糖醛酸、聚半乳糖或聚阿拉伯糖。组合物还可以包含其他成分，如草药提取物、抗氧化剂成分、润肤剂成分、螯合剂、溶剂成分或防腐剂成分。该组合物可用作皮肤保护剂。
• Emulsified skin care composition containing salicylic acid, lanolin oil, and propylene glycol
  申请人：Alwyn Company, Inc.

  公开号：US20030157137A1

  公开（公告）日：2003-08-21

  A composition comprising an oil-in-water emulsion for skin care containing salicylic acid or another hydroxy acid, and propylene glycol to prevent formation of crystals of the hydroxy acid. The composition includes, as an emulsifier, at least one nonionic polyoxyethylene ether with a HLB of about 15 to about 17; in some embodiments, another nonionic polyoxyethylene ether with a HLB of 10 to 12 is also included. The composition also includes lanolin oil and a complex comprising Vitamin A and Vitamin D 3 . Other ingredients, such as a hydrophilic carbohydrate-containing polymer or a quaternary ammonium-containing polymer, can be included. Still other ingredients, such as preservatives, chelators, herbal extracts, allantoin and fragrance, can be included. Another aspect of the invention is a method of use of a composition according to the present invention in treating dermatological or systemic inflammatory conditions such as psoriasis, seborrheic dermatitis, and dandruff.

  一种水包油型护肤乳液组合物，含有水杨酸或另一种羟基酸，以及防止羟基酸结晶形成的丙二醇。该组合物包括至少一种 HLB 值约为 15 至 17 的非离子聚氧乙烯醚作为乳化剂；在某些实施方案中，还包括另一种 HLB 值为 10 至 12 的非离子聚氧乙烯醚。该组合物还包括羊毛脂油和由维生素 A 和维生素 D 组成的复合物 3 .还可包括其他成分，如亲水性含碳水化合物聚合物或含季铵聚合物。还可以加入其他成分，如防腐剂、螯合剂、草药提取物、尿囊素和香料。本发明的另一个方面是根据本发明的组合物用于治疗皮肤病或全身炎症，如牛皮癣、脂溢性皮炎和头皮屑的方法。