Rose Bengal (sodium)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Rose Bengal (sodium)
• 英文别名: disodium;4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
• 化学式: C20H2Cl4I4Na2O5
• 分子量: 1017.6
• InChiKey: KCQREHTWEUECQT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  35
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  81.6
• 氢给体数：
  0
• 氢受体数：
  5

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

文献信息

• METHOD OF PREVENTING FADING OF TAR COLORANT AND TAR COLORANT-CONTAINING COMPOSITION WITH PREVENTED FADING
  申请人：SAN-EI GEN F.F.I., INC.

  公开号：EP1752498A1

  公开（公告）日：2007-02-14

  The present invention provides a method of suppressing fading of a tar colorant. More specifically, the present invention provides a method of suppressing a tar colorant fading phenomenon that occurs specifically in compositions containing (a) the tar colorant, and (b) at least one of reducing sugars, ascorbic acid compounds, or metals. This method can be attained by mixing (c) at least one selected from the group consisting Of isoquercitrin, enzymatically modified isoquercitrin, rutin, enzymatically modified rutin, Chinese bayberry extract, and rosemary extract into such a composition, thus making the component (a), the component (b) and the component (c) coexist. The present invention further provides a composition for which fading of a tar colorant is suppressed using the above method, more specifically a composition containing at least one of reducing sugars, ascorbic acid compounds, or metals in addition to the tar colorant.

  本发明提供了一种抑制焦油着色剂褪色的方法。更具体地说，本发明提供了一种抑制焦油着色剂褪色现象的方法，这种现象特别发生在含有(a) 焦油着色剂和(b) 还原糖、抗坏血酸化合物或金属中的至少一种的组合物中。这种方法可以通过将(c)至少一种选自异槲皮素、酶法改性异槲皮素、芦丁、酶法改性芦丁、杨梅提取物和迷迭香提取物组成的组中的一种混合到这种组合物中，从而使组分(a)、组分(b)和组分(c)共存来实现。本发明进一步提供了一种使用上述方法可抑制焦油着色剂褪色的组合物，更具体地说，是一种除焦油着色剂外还含有还原糖、抗坏血酸化合物或金属中至少一种的组合物。
• INKJET INK AND TABLET
  申请人：Toppan Printing Co., Ltd.

  公开号：EP3778795A1

  公开（公告）日：2021-02-17

  There is provided an inkjet ink in which a food color containing at least sodium copper chlorophyllin and a pigment other than sodium copper chlorophyllin is dispersed in a dispersion medium containing propylene glycol, and which prevents the occurrence of precipitation of the pigment components or other components even when the inkjet ink is stored for a long period of time, and there is also provided a tablet having a print pattern printed by the inkjet ink. The inkjet ink of the present embodiment, which is edible, comprises a food color containing at least sodium copper chlorophyllin and a pigment other than sodium copper chlorophyllin, and a dispersion medium containing propylene glycol, and has a propylene glycol content in the range of 0.001 mass% or more and 19 mass% or less relative to the total mass of the inkjet ink.

  本发明提供了一种喷墨墨水，在该墨水中，含有至少叶绿素铜钠和叶绿素铜钠以外的颜料的食用色素被分散在含有丙二醇的分散介质中，即使喷墨墨水被长期储存，也能防止颜料成分或其他成分发生沉淀，本发明还提供了一种具有由该喷墨墨水打印图案的药片。本发明实施例中的喷墨墨水是可食用的，包括至少含有叶绿素铜钠和叶绿素铜钠以外的颜料的食用色素，以及含有丙二醇的分散介质，相对于喷墨墨水的总质量，丙二醇的含量在 0.001 质量%或以上、19 质量%或以下的范围内。
• BLUE INKJET INK AND TABLET
  申请人：Toppan Printing Co., Ltd.

  公开号：EP3778800A1

  公开（公告）日：2021-02-17

  The present invention aims to provide a blue ink-jet ink that improves lightfastness of the same while maintaining its blue print color and a tablet including a part printed with the blue ink-jet ink. The blue ink-jet ink according to the present embodiment is an edible ink-jet that contains Brilliant Blue FCF (Blue No. 1 Colorant) and New Coccine (Red No. 102 Colorant) as colorants.

  本发明旨在提供一种蓝色喷墨墨水，在保持其蓝色印刷色的同时提高其耐光性，并提供一种包括用该蓝色喷墨墨水印刷的部分的片剂。根据本发明实施例的蓝色喷墨墨水是一种可食用喷墨墨水，它含有艳蓝 FCF（蓝色 1 号着色剂）和新可可碱（红色 102 号着色剂）作为着色剂。
• COMPOUNDS FOR THE TREATMENT OF COVID-19
  申请人：Dompe' Farmaceutici S.P.A.

  公开号：EP3875078A1

  公开（公告）日：2021-09-08

  The present invention relates to compounds that are able to inhibt 3CL protease of COVID-19 virus, SARS-Cov-2

  本发明涉及能够抑制 COVID-19 病毒、SARS-Cov-2 病毒的 3CL 蛋白酶的化合物。
• APPLICATION OF AMINO ACID NUTRIENT, AND PHARMACEUTICAL COMPOSITION INCLUDING AMINO ACID NUTRIENT
  申请人：Chengdu Kuachangaopu Medical Technology Co., Ltd.

  公开号：EP3845247A1

  公开（公告）日：2021-07-07

  A pharmaceutical composition including a high concentration amino acid nutrient and a synergist thereof, an apparatus including said composition, and a use of said composition in preparing a pharmaceutical composition which treats topical lesion diseases.

  一种包括高浓度氨基酸营养素及其增效剂的药物组合物，一种包括所述组合物的装置，以及所述组合物在制备治疗局部病变疾病的药物组合物中的用途。

表征谱图