Parvaquone | 4042-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Parvaquone
• 英文别名: 3-cyclohexyl-4-hydroxynaphthalene-1,2-dione
• CAS: 4042-30-2
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.3
• InChiKey: XBGHCDVBZZNDBY-UHFFFAOYSA-N

物化性质

• 熔点：
  135-136°
• 沸点：
  421.3±45.0 °C(Predicted)
• 密度：
  1.310

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2914690090

文献信息

• Methods of treating cancer with atovaquone-related compounds
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US10130590B2

  公开（公告）日：2018-11-20

  Described herein are, inter alia, methods for decreasing the growth of a cancer cell, the method comprising delivering to a target cancer cell a growth-inhibitory amount of an atovaquone-related compound, wherein, prior to the delivery, an increased level of activation of the mTOR pathway in the cancer compared to a control level of activation of the mTOR pathway has been found. Also provided are methods for determining the susceptibility of cancer to treatment with an atovaquone-related compound and for assessing the success of therapy with such a compound.

  本文特别描述了减少癌细胞生长的方法，该方法包括向目标癌细胞递送抑制生长量的阿托伐醌相关化合物，其中，在递送之前，与mTOR通路的对照激活水平相比，已发现癌细胞中mTOR通路的激活水平增加。此外，还提供了确定癌症对阿托伐醌相关化合物治疗的易感性以及评估这种化合物治疗成功与否的方法。
• Methods of Treating Cancer with Atovaquone-Related Compounds
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20160296480A1

  公开（公告）日：2016-10-13

  Described herein are, inter alia, methods for decreasing the growth of a cancer cell, the method comprising delivering to a target cancer cell a growth-inhibitory amount of an atovaquone-related compound, wherein, prior to the delivery, an increased level of activation of the mTOR pathway in the cancer compared to a control level of activation of the mTOR pathway has been found. Also provided are methods for determining the susceptibility of cancer to treatment with an atovaquone-related compound and for assessing the success of therapy with such a compound.
• [EN] METHODS OF TREATING CANCER WITH ATOVAQUONE-RELATED COMPOUNDS<br/>[FR] PROCÉDÉS DE TRAITEMENT ANTICANCÉREUX PAR DES COMPOSÉS APPARENTÉS À L'ATOVAQUONE
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2015050844A1

  公开（公告）日：2015-04-09

  Described herein are, inter alia, methods for decreasing the growth of a cancer cell, the method comprising delivering to a target cancer cell a growth-inhibitory amount of an atovaquone-related compound, wherein, prior to the delivery, an increased level of activation of the mTOR pathway in the cancer compared to a control level of activation of the mTOR pathway has been found. Also provided are methods for determining the susceptibility of cancer to treatment with an atovaquone-related compound and for assessing the success of therapy with such a compound.
• [EN] COMPOSITIONS AND METHODS RELATED TO DISSOLVED OXIDES<br/>[FR] COMPOSITIONS ET PROCÉDÉS ASSOCIÉS À DES OXYDES DISSOUS
  申请人：NATURAL EXTRACTION SYS LLC

  公开号：WO2021042001A1

  公开（公告）日：2021-03-04

  Various aspects of this patent document relate to compositions that comprise an anion that is the conjugate base of a hydrophobic molecule that has a pKa, for example, of at least 7 and no greater than 12. These compositions display improved properties when formulated to interact with an organism because the anions carry negative charges that allows them to both dissolve in water-miscible liquids and maximize their surface area. Interaction with an organism results in at least partial conversion of the anion into the hydrophobic molecule after which the hydrophobic molecule partitions out of a water-miscible liquid and into the organism.