6-Amino-2-(hydrazinecarbonylamino)-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid | 67769-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-Amino-2-(hydrazinecarbonylamino)-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid
• CAS: 67769-47-5
• 化学式: C₁₃H₁₁N₅O₉S₂
• 分子量: 445.4
• InChiKey: OVPVVOAYSGVQSZ-UHFFFAOYSA-N

物化性质

• 熔点：
  >200 ℃
• 溶解度：
  水中的溶解度为1mg/mL
• 最大波长(λmax)：
  280nm, 428nm

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  256
• 氢给体数：
  6
• 氢受体数：
  11

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Lucifer Yellow CH（二锂盐）是一种高荧光染料，可用于标记神经细胞。该染料被认为对细胞无毒，具有膜不透过性，在生理pH值下呈高度游离状态。

文献信息

• Methods of modulating neurotrophin-mediated activity
  申请人：Babinski Kazimierz

  公开号：US20070093474A1

  公开（公告）日：2007-04-26

  Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  本发明涉及一种调节神经生长因子及其前体与神经营养受体相互作用的组合物。本发明还涉及使用该组合物的方法，包括给药方法。
• ANALYSIS OF CARBOHYDRATES AND KITS THEREFORE
  申请人：ASTROSCAN LIMITED

  公开号：EP0595806A1

  公开（公告）日：1994-05-11
• NOVEL COLORANTS AND COLORANT MODIFIERS
  申请人：Kimberly-Clark Worldwide, Inc.

  公开号：EP0804511A1

  公开（公告）日：1997-11-05
• ADVANCED METHODS FOR AUTOMATED HIGH-PERFORMANCE IDENTIFICATION OF CARBOHYDRATES AND CARBOHYDRATE MIXTURE COMPOSITION PATTERNS AND SYSTEMS THEREFORE AS WELL AS METHODS FOR CALIBRATION OF MULTI WAVELENGTH FLUORESCENCE DETECTION SYSTEMS THEREFORE, BASED ON NEW FLUORESCENT DYES
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V

  公开号：US20220026434A1

  公开（公告）日：2022-01-27

  The present invention relates to improved (simplified/easier, more robust and more reproducible) methods for identification of carbohydrates compositions, e.g. out of complex carbohydrate mixtures, as well as the determination of carbohydrate mixture composition patterns (e.g.: of glycosylation patterns) based on advanced internal standards to determine precise and highly reproducible migration and retention time indices using novel fluorescent dyes in combination with high performance separation technologies, like capillary (gel) electrophoresis (C(G)E) or (ultra)high performance liquid chromatography (U)HPLC with a highly sensitive detection like (laser induced) fluorescence detection. In a first aspect, the present invention relates to methods for an automated determination and/or identification of carbohydrates and/or carbohydrate mixture composition pattern profiling as well as a method for an automated carbohydrate mixture composition pattern profiling based on the use of at least a first and second fluorescent label for labelling the migration/retention time alignment standard and sample or different samples, respectively, whereby the at least one of that fluorescent dye is a compound as defined herein. Moreover, the present invention relates to a method for calibration of multi wavelength fluorescence detection systems as well as calibration systems or calibration standards and new compounds suitable for calibration are described. The present invention relates further to a kit or system for determining or identifying carbohydrate mixture composition patterns as well as a kit or system for determining and/or identifying carbohydrate mixture composition pattern. Further, a carbohydrate dye conjugate comprising the dye as defined herein for use in a method according to the present invention is provided. The dyes employed for forming the carbohydrate dye conjugate have formula A or B below:
• US7579468B2
  申请人：——

  公开号：US7579468B2

  公开（公告）日：2009-08-25