dilithium;6-amino-2-(hydrazinecarbonylamino)-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dilithium;6-amino-2-(hydrazinecarbonylamino)-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonate
• 化学式: C13H9Li2N5O9S2
• 分子量: 457.3
• InChiKey: RPKCZJYDUKVMGF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -8.08
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  262
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• [EN] PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA<br/>[FR] SONDES POUR LA DÉTECTION RAPIDE ET SPÉCIFIQUE DE MYCOBACTÉRIES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017027062A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β- lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.

  本公开的组成提供了新颖的生色团探针，用于特定地成像和检测分枝杆菌种类，尤其是对β-内酰胺类抗生素具有抗药性的种类。这些探针通过引入一种特定针对分枝杆菌中DprE1独特捕获机制的基团，从而实现对分枝杆菌的特异性。因此，只有表达β-内酰胺酶和DprE1的分枝杆菌种类才能激活笼状荧光探针，并通过功能性还原-共价结合机制将释放的荧光探针固定到细菌细胞上。这种探针的一个显著优点是，在其最敏感的情况下，能够实现单个分枝杆菌的检测。
• [EN] COMPOUNDS AND METHODS FOR DETECTION OF HYDROGEN PEROXIDE<br/>[FR] COMPOSÉS ET PROCÉDÉS DE DÉTECTION DE PEROXYDE D'HYDROGÈNE
  申请人：UNIV HONG KONG

  公开号：WO2018133859A1

  公开（公告）日：2018-07-26

  Disclosed herein are compounds and methods for using the same for the detection of hydrogen peroxide in situ. The compounds can include compounds of Formula (I), Formula (II), or Formula (III), or a salt thereof, wherein X1 is a monovalent pro-fluorophore or pro-luminophore moiety; X2 is a divalent pro-fluorophore or pro-luminophore moiety; each of A and A' is independently represented by formula (IV) or formula (V) :

  披露的是用于现场检测过氧化氢的化合物及其使用方法。这些化合物可以包括公式(I)、公式(II)或公式(III)的化合物，或其盐，其中X1是单价原荧光体或原发光体基团；X2是二价原荧光体或原发光体基团；A和A'每个独立地由公式(IV)或公式(V)表示：
• Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues
  申请人：ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

  公开号：US10020455B2

  公开（公告）日：2018-07-10

  A phosphorescent emitter or delayed fluorescent and phosphorescent emitters represented by Formula 1 or Formula II, where M is platinum or palladium.

  根据您的要求，翻译结果如下： 一个磷光发射器或延迟荧光和磷光发射器，由公式1或公式II表示，其中M是铂或钯。
• Tetradentate Platinum And Palladium Complex Emitters Containing Phenyl-Pyrazole And Its Analogues
  申请人：Li Jian

  公开号：US20150194616A1

  公开（公告）日：2015-07-09

  A phosphorescent emitter or delayed fluorescent and phosphorescent emitters represented by Formula 1 or Formula II, where M is platiunum or palladium.

  一个磷光发射器或延迟荧光和磷光发射器，由公式1或公式II表示，其中M是铂或钯。