1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane;hydron;chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane;hydron;chloride
• 化学式: C15H18Cl2N2O2S
• mdl: MFCD00065525
• 分子量: 361.3
• InChiKey: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-氯萘-1-磺酰氯 、 高哌嗪 生成 1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane;hydron;chloride
  参考文献：
  名称：

  XIDAKA, XIROESI;TANAKA, TOSIO;ITO, YASUO;KATO, XIDEHO;EHTTYU, EHJITI;OGAV+

  摘要：

  DOI：

文献信息

• CRYSTALLINE FORMS OF C21H22Cl2N4O2
  申请人：BIOMED VALLEY DISCOVERIES, INC.

  公开号：US20170320851A1

  公开（公告）日：2017-11-09

  The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

  本发明提供了公式（I）化合物的晶体形式。还提供包含所提供晶体形式的药物组合物以及使用所提供的晶体形式和药物组合物治疗癌症的方法。
• CRYSTALLINE C21H22Cl2N4O2 MALONATE
  申请人：BIOMED VALLEY DISCOVERIES, INC.

  公开号：US20160221988A1

  公开（公告）日：2016-08-04

  The present invention provides a malonate salt of a compound of formula (I): which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

  本发明提供了公式（I）化合物的马隆酸盐，该盐为晶体盐。还提供了包含所提供的马隆酸盐的药物组合物以及使用所提供的晶体形式和药物组合物治疗癌症的方法。
• GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING SAME
  申请人：Aeon Medix Inc.

  公开号：EP2494865A2

  公开（公告）日：2012-09-05

  The present invention relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present invention relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that occur due to gut flora-derived extracellular vesicles, and to a vaccine which can efficiently prevent or treat infections caused by gut flora or diseases that occur due to gut flora-derived extracellular vesicles. Further, the development of diagnostic technology to discover, using the gut flora-derived extracellular vesicles of the present invention, the etiology of diseases that occur due to gut flora-derived extracellular vesicles, can be achieved.

  本发明涉及一种包括源自肠道菌群的细胞外囊泡的组合物，以及使用该组合物的动物疾病模型。此外，本发明还涉及一种使用肠道菌群衍生的胞外囊泡来有效寻找候选药物的方法，该候选药物可预防或治疗因肠道菌群衍生的胞外囊泡而发生的疾病；本发明还涉及一种疫苗，该疫苗可有效预防或治疗由肠道菌群引起的感染或因肠道菌群衍生的胞外囊泡而发生的疾病。此外，还可以开发诊断技术，利用本发明的肠道菌群源性细胞外囊泡发现因肠道菌群源性细胞外囊泡引起的疾病的病因。
• CANCER TREATMENTS USING COMBINATIONS OF TYPE 2 MEK AND ERK INHIBITORS
  申请人：Biomed Valley Discoveries, Inc.

  公开号：EP3984537A1

  公开（公告）日：2022-04-20

  The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method includes administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD 523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 2 MEK inhibitor, or other MEK inhibitors, or pharmaceutically acceptable salts thereof, to treat or ameliorate the effects of the cancer. Additional methods for effecting cancer cell death are also provided.

  本发明特别提供了用于治疗或改善有需要的受试者的癌症影响的方法、试剂盒和药物组合物。该方法包括向受试者施用有效量的(i)第一种抗癌剂，即BVD 523或其药学上可接受的盐和(ii)第二种抗癌剂，即2型MEK抑制剂或其他MEK抑制剂或其药学上可接受的盐，以治疗或改善癌症的影响。此外，还提供了其他使癌细胞死亡的方法。
• Crystalline forms of C21H22Cl2N4O2
  申请人：BIOMED VALLEY DISCOVERIES, INC.

  公开号：US10183927B2

  公开（公告）日：2019-01-22

  The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

  本发明提供了式 (I) 化合物的结晶形式： 还提供了包括所提供晶体形式的药物组合物，以及使用所提供晶体形式和药物组合物治疗癌症的方法。