N,N-diethyl-2-[4-(5-methoxy-2-phenyl-3H-inden-1-yl)phenoxy]ethanamine;hydron;chloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N,N-diethyl-2-[4-(5-methoxy-2-phenyl-3H-inden-1-yl)phenoxy]ethanamine;hydron;chloride
• 化学式: C28H32ClNO2
• 分子量: 450.0
• InChiKey: REUSRIYEEARJHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.35
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  21.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Trans-clomiphene for treating diabetes in hypogonadal men
  申请人：Repros Therapeutics Inc.

  公开号：EP2826475A1

  公开（公告）日：2015-01-21

  The present invention relates to the administration of compositions comprising an antiestrogen, preferably trans-clomiphene, for treating metabolic syndrome in a subject. The invention is also directed to methods for reducing fasting glucose levels in a subject by administering a composition comprising an antiestrogen, preferably trans-clomiphene.

  本发明涉及施用包含抗雌激素（最好是反式-克罗米芬）的组合物治疗受试者的代谢综合征。本发明还涉及通过施用包含抗雌激素（最好是反式-氯米芬）的组合物来降低受试者空腹血糖水平的方法。
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• COMBINATION THERAPY FOR TREATING ANDROGEN DEFICIENCY
  申请人：Repros Therapeutics Inc.

  公开号：EP2819676A1

  公开（公告）日：2015-01-07
• TRANS-CLOMIPHENE FOR USE IN CANCER THERAPY
  申请人：Repros Therapeutics Inc.

  公开号：EP2914294A1

  公开（公告）日：2015-09-09
• METHODS AND COMPOSITIONS WITH TRANS-CLOMIPHENE
  申请人：Podolski S. Joseph

  公开号：US20070249726A1

  公开（公告）日：2007-10-25

  The present invention relates to the use of compositions comprising trans-clomiphene for treating wasting, especially a loss of muscle mass. The invention is also directed to methods for treating wasting in a patient with chronic obstructive pulmonary disorder. The present invention is also directed to methods for treating hypogonadism in males with chronic obstructive pulmonary disorder.