(2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl)propionic acid | 150612-55-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl)propionic acid
• 英文别名: DX-9065a；(2s)-3-(7-Carbamimidoylnaphthalen-2-Yl)-2-[4-({(3r)-1-[(1z)-Ethanimidoyl]pyrrolidin-3-Yl}oxy)phenyl]propanoic Acid；(2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-[4-[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxyphenyl]propanoic acid
• CAS: 150612-55-8
• 化学式: C₂₆H₂₈N₄O₃
• 分子量: 444.533
• InChiKey: AGRCGQSFFMCBRE-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• SUBSTITUTED OXAZOLIDINONES AND THEIR USE
  申请人：Allerheiligen Swen

  公开号：US20100261759A1

  公开（公告）日：2010-10-14

  The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.

  这项发明涉及新型取代氧唑烷酮，其制备方法，其用于治疗和/或预防疾病以及用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物。
• 2-(HETEROARYL) ALKYL INDAZOLE 6-PHENYL AND THIENYL METHYL AMIDE AS THROMBIN INHIBITORS
  申请人：Siegel Stephan

  公开号：US20100105663A1

  公开（公告）日：2010-04-29

  The invention relates to substituted indazoles and methods for production thereof and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases, preferably of thromboembolic diseases.

  该发明涉及取代吲唑并且生产方法以及用于制备治疗和/或预防疾病的药物的用途，特别是心血管疾病，最好是血栓栓塞疾病。
• INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR
  申请人：Gretler Daniel D.

  公开号：US20090048216A1

  公开（公告）日：2009-02-19

  The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.

  该发明提供了一种用于快速和可逆地抑制人体内需要的血小板聚集的方法和组合物，通过给予以下化合物的方式：单独或与第二药物联合使用，第二药物可以是阿司匹林或溶栓剂。
• SORBEFACIENTS
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0966973A1

  公开（公告）日：1999-12-29

  Pharmaceutical compositions for improving the absorption of drugs having poor absorbability in the digestive tract. The compositions contain drugs and anion exchange resins and show excellent absorbability in the digestive tract.

  药物组合物，用于提高消化道内吸收性差的药物的吸收。该组合物包含药物和阴离子交换树脂，能够在消化道内表现出极佳的吸收性。
• MEDICINAL COMPOSITION FOR PERCUTANEOUS ADMINISTRATION
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1043020A1

  公开（公告）日：2000-10-11

  A percutaneously absorbable medicinal composition comprising a percutaneous absorption enhancer and at least one member selected from the group consisting of aromatic amidine derivatives represented by formula (1): salts of the derivatives, solvates of the derivatives, and solvates of salts of the derivatives. The present invention provides a composition which exhibits high percutaneous absorbability, which can maintain an effective blood level for prolonged periods of time, which provides antithrombotic and anticoagulant effects.

  一种经皮吸收的药物组合物，包括经皮吸收增强剂以及选择自式（1）所表示的芳香族酰胺衍生物的至少一种成员：衍生物的盐，衍生物的溶剂，以及衍生物的盐的溶剂。本发明提供了一种组合物，具有高经皮吸收性，可以维持有效的血液水平长时间，具有抗血栓和抗凝血作用。